Results 131 to 140 of about 1,699,826 (261)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Human and mouse regenerative macrophages enhance beta cell survival, function, and proliferation. [PDF]

Islets
Monajemi M, Craciun AS, Huang Q, Dai L, Mojibian M, Crome SQ, Verchere CB, Levings MK.   +7 more
europepmc   +1 more source

TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity. [PDF]

Cell Rep, 2019
Hurrell BP, Galle-Treger L, Jahani PS, Howard E, Helou DG, Banie H, Soroosh P, Akbari O.   +7 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Nonparametric estimation of conditional survival function with time-varying covariates using DeepONet. [PDF]

Lifetime Data Anal
Hu B, Nan B.
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evaluating the effect of CD47 expression levels and clinicopathologic features on survival function in resected uterine carcinosarcoma: the Western Turkey example. [PDF]

BMC Cancer
Keser M, Semiz HS, Cakir I, Muharremoglu ZD, Unal OU, Akagunduz B, Pala EE.   +6 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Total wrist arthroplasty revisited: survival, function, and patient-reported outcomes of BIAX and universal II prostheses over 15 years. [PDF]

Arch Orthop Trauma Surg
Mandl L, Gruber A, Horch RE, Demir R.
europepmc   +1 more source

Reoperation Rates after Laminoplasty for Cervical Disorders: A 26-Year Period Survival Function Method Analysis. [PDF]

Spine Surg Relat Res, 2019
Hashimoto K, Aizawa T, Ozawa H, Tanaka Y, Kusakabe T, Morozumi N, Koizumi Y, Sato T, Hyodo H, Nakagawa T, Takahashi E, Hoshikawa T, Imaizumi H, Ogawa S, Kasama F, Kanno H, Itoi E, Kokubun S.   +17 more
europepmc   +1 more source