Results 131 to 140 of about 1,779,093 (216)

Synovial IL-9 facilitates neutrophil survival, function and differentiation of Th17 cells in rheumatoid arthritis. [PDF]

Arthritis Res Ther, 2018
Chowdhury K, Kumar U, Das S, Chaudhuri J, Kumar P, Kanjilal M, Ghosh P, Sircar G, Basyal RK, Kanga U, Bandyopadhaya S, Mitra DK.   +11 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Using Age-Specific Rates for Parametric Survival Function Estimation in Simulation Models. [PDF]

Med Decis Making
Arrospide A, Ibarrondo O, Blasco-Aguado R, Larrañaga I, Alarid-Escudero F, Mar J.   +5 more
europepmc   +1 more source

Pro-survival function of MEF2 in cardiomyocytes is enhanced by β-blockers. [PDF]

Cell Death Discov, 2015
Hashemi S, Salma J, Wales S, McDermott JC.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comparison of survival, function and complication between intercalary frozen autograft versus massive allograft reconstruction after malignant bone tumors resection. [PDF]

J Orthop Traumatol
Li Z, Guo H, Deng Z, Yang Y, Zhang Q, Liu W.   +5 more
europepmc   +1 more source

The pro-survival function of DLEC1 and its protection of cancer cells against 5-FU-induced apoptosis through up-regulation of BCL-XL. [PDF]

Cytotechnology, 2019
Qiu GH, Que W, Yan S, Zheng X, Xie X, Huang C, Yang X, Hooi SC.   +7 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Combination of bortezomib and venetoclax targets the pro-survival function of LMP-1 and EBNA-3C of Epstein-Barr virus in spontaneous lymphoblastoid cell lines. [PDF]

PLoS Pathog
Tam KP, Xie J, Au-Yeung RKH, Chiang AKS.
europepmc   +1 more source

A fully nonparametric estimator of the marginal survival function based on case-control clustered age-at-onset data. [PDF]

Biostatistics, 2017
Gorfine M, Bordo N, Hsu L.
europepmc   +1 more source