Results 121 to 130 of about 17,500,545 (334)

β-Hydroxybutyrate improves β-cell mitochondrial function and survival

Journal of Metabolic Health, 2017
Pharmacological interventions aimed at improving outcomes in type 2 diabetes and achieving normoglycaemia, including insulin therapy, are increasingly common, despite the potential for substantial side effects.
MaryJane Sampson, Daniel R. Lathen, Blake W. Dallon, Carrie Draney, Jason D. Ray, Kyle B. Kener, Brian A. Parker, Jonathan L. Gibbs, Jarom S. Gropp, Jeffery S. Tessem, Benjamin T. Bikman   +10 more
doaj   +1 more source

Transition from the annealed to the quenched asymptotics for a random walk on random obstacles

, 2005
In this work we study a natural transition mechanism describing the passage from a quenched (almost sure) regime to an annealed (in average) one, for a symmetric simple random walk on random obstacles on sites having an identical and independent law. The
Arous, Gérard Ben, Molchanov, Stanislav, Ramírez, Alejandro F.   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Differentially Private Survival Function Estimation

, 2019
Preprint
Gondara, Lovedeep, Wang, Ke
openaire   +2 more sources

Survival Probability in Patients with Sickle Cell Anemia Using the Competitive Risk Statistical Model. [PDF]

, 2019
The clinical picture of patients with sickle cell anemia (SCA) is associated with several complications some of which could be fatal. The objective of this study is to analyze the causes of death and the effect of sex and age on survival of Brazilian ...
Ballas, Samir K., de Bragança Pereira, Basilio, de Castro Lobo, Clarisse Lopes, do Nascimento, Emilia Matos   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Thyroid function and survival following breast cancer

British Journal of Surgery, 2016
Abstract Background Thyroid function has been associated with breast cancer risk, and breast cancer cell growth and proliferation. It is not clear whether thyroid function affects prognosis following breast cancer but, if so, this could have an important clinical impact.
J, Brandt, S, Borgquist, M, Almquist, J, Manjer   +3 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Novel Entropy‐Transformed Inverse Weibull Distribution: Development, Properties, and Application in Diverse Data Modeling

Engineering Reports
Standard distributions must be improved to enhance their capacity for data modeling because they do not inherently suit all sorts of data sets in an acceptable manner.
Tabassum Naz Sindhu, Anum Shafiq, Qasem M. Al‐Mdallal, Tahani A. Abushal, Muhammad Aslam   +4 more
doaj   +1 more source

Survival and Function of Islets during Culture

Cell Transplantation, 1996
Cell and tissue culture techniques have improved considerably since the first attempts to maintain explants of animal tissue in vitro. The two major developments that have allowed these improvements are the ability to produce continuous cell lines, thus ...
Heather A. Clayton, Nick J.M. London
doaj   +1 more source