Results 111 to 120 of about 174,614,231 (302)

Exercise attenuates polyglutamine‐mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy

Journal of Cachexia, Sarcopenia and Muscle
Background Spinal and bulbar muscular atrophy (SBMA) is a hereditary neuromuscular disorder caused by the expansion of trinucleotide cytosine–adenine–guanine (CAG) repeats, which encodes a polyglutamine (polyQ) tract in the androgen receptor (AR) gene ...
Tomoki Hirunagi, Hideaki Nakatsuji, Kentaro Sahashi, Mikiyasu Yamamoto, Madoka Iida, Genki Tohnai, Naohide Kondo, Shinichiro Yamada, Ayuka Murakami, Seiya Noda, Hiroaki Adachi, Gen Sobue, Masahisa Katsuno   +12 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Scaling proprioceptor gene transcription by retrograde NT3 signaling [PDF]

, 2011
The assembly of neuronal circuits depends critically on the sequential activation of transcriptional programs in defined neuronal sub-populations. In the spinal cord, retrograde signaling interactions from the periphery have been shown to be essential ...
Lee, Jun
core   +1 more source

The efficacy and safety of Nusinersen for spinal muscular atrophy types 1, 2, 3: a systematic review of the current evidence

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Spinal muscular atrophy (SMA) is a severe genetic neuromuscular disorder characterized by muscle atrophy and weakness due to motor neuron loss. It results from mutations in the SMN1 gene, leading to insufficient SMN protein, which is essential
Somaia Daghriri, Yara A. Alorfi, Rasil Sulaiman Alayed, Wid F. Altaf, Ghaida E. Alharbi, Hisham Alsulami, Raghad Alkhalifah, Omar Alzahrani, Abdulrahman Softah   +8 more
doaj   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Functional genetic analysis of motor neuron disease [PDF]

, 2010
Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the commonest motor neuron diseases of adult- and childhood onset. Alterations of the RNA binding protein TDP-43 are associated with most cases of ALS, while SMA is caused by ...
Bäumer, Dirk
core   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

History of the Ohio Bureau of Motor Vehicles

, 2001
Title from caption (viewed Mar.
Ohio. Bureau of Motor Vehicles.
core  

Survival motor neuron protein facilitates assembly of stress granules [PDF]

, 2004
The survival motor neuron (SMN) protein forms cytoplasmic granules when overexpressed. We report here that SMN co-localizes with TIA-1/R and G3BP, protein assemblers of stress granules (SGs), and that SMN is co-immunoprecipitated with TIA-1/R, suggesting
Zhou, Jianhua, Hua, Yimin
core   +1 more source

A comparison of three electrophysiological methods for the assessment of disease status in a mild spinal muscular atrophy mouse model.

PLoS ONE, 2014
OBJECTIVES:There is a need for better, noninvasive quantitative biomarkers for assessing the rate of progression and possible response to therapy in spinal muscular atrophy (SMA).
Jia Li, Tom R Geisbush, William D Arnold, Glenn D Rosen, Phillip G Zaworski, Seward B Rutkove   +5 more
doaj   +1 more source