Results 241 to 250 of about 73,691 (271)

Diagnostic Pitfalls in Adult-Onset Spinal Muscular Atrophy Type 4: When Incidental Lumbar Stenosis Confounds the Clinical Picture. [PDF]

Cureus
Rafique S, Rafiq I.
europepmc   +1 more source

Taming the "death receptor": translating the first-in-class p75^NTR modulator LM11A-31 from basic biology, across broad preclinical models, to clinical proof-of-concept. [PDF]

J Transl Med
Langness VF, Simmons DA, Kaur S, Massa SM, Longo FM.   +4 more
europepmc   +1 more source

Spinal motor neuron degeneration after brachial plexus avulsion: mechanisms and therapeutic targets. [PDF]

Front Neurosci
Yang J, Qin B, Yang Y, Fang J, He W.
europepmc   +1 more source

ATH-1105 mitigates multiple pathologies in ALS models both alone and in combination with riluzole. [PDF]

Front Neurol
Berthiaume AA, Kleist KN, Reda SM, Setti SE, Wu W, Johnston JL, Taylor RW, Stein LR, Church KJ.   +8 more
europepmc   +1 more source

Early mitochondrial gene dysregulation precedes motor neuron degeneration in genomically humanised FUS mutant mice

Price G, de Azambuja G, Williams C, Thompson D, Tibbit C, Ali Z, Austin A, Ahmed M, Tosolini A, Devoy A, Codner GF, Teboul L, Greensmith L, Schiavo G, Cruz Sd, Fisher EM, Cunningham TJ.   +16 more
europepmc   +1 more source

The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy

Neuromuscular Disorders, 2019
Spinal muscular atrophy (SMA) is a rare genetic and progressively debilitating neuromuscular disease. It is the leading genetic cause of death among infants. In SMA, low levels of survival of motor neuron (SMN) protein lead to motor neuron death and muscle atrophy as the SMN protein is critical to motor neuron survival.
Heidemarie Kletzl, Anne Marquet, Andreas Günther, Wakana Tang, Jules Heuberger, Geert Jan Groeneveld, Willem Birkhoff, Eugenio Mercuri, Hanns Lochmüller, Claire Wood, Dirk Fischer, Irene Gerlach, Katja Heinig, Teodorica Bugawan, Sebastian Dziadek, Russell Kinch, Christian Czech, Omar Khwaja   +17 more
openaire   +5 more sources

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice

Neurobiology of Aging, 2014
Spinal muscular atrophy results from diminished levels of survival motor neuron (SMN) protein in spinal motor neurons. Low levels of SMN also occur in models of amyotrophic lateral sclerosis (ALS) caused by mutant superoxide dismutase 1 (SOD1) and ...
Bradley J Turner, Rebecca K Sheean, James N Sleigh   +2 more
exaly   +2 more sources