Results 61 to 70 of about 73,691 (271)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A QSAR study to predict the survival motor neuron promoter activity of candidate diaminoquinazoline derivatives for the potential treatment of spinal muscular atrophy

, 2023
Spinal Muscular Atrophy is a genetic neuromuscular disease that leads to muscle weakness and atrophy and it is characterized by the loss of α-motor neurons in the spinal cord\"s anterior horn cells.
ERDEM, SAFİYE
core   +2 more sources

Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment

Acta Neuropathologica Communications
Mutations in the ANXA11 gene, encoding an RNA-binding protein, have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but the underlying in vivo mechanisms remain unclear.
Qing Liu, Ye Sun, Baodong He, Haodong Chen, Lijing Wang, Gaojie Wang, Kang Zhang, Ximeng Zhao, Xinzhe Zhang, Dongchao Shen, Xue Zhang, Liying Cui   +11 more
doaj   +1 more source

Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila. [PDF]

PLoS ONE, 2015
The SMN-Gemins complex is composed of Gemins 2-8, Unrip and the survival motor neuron (SMN) protein. Limiting levels of SMN result in the neuromuscular disorder, spinal muscular atrophy (SMA), which is presently untreatable.
Rebecca M Borg, Rémy Bordonne, Neville Vassallo, Ruben J Cauchi   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The efficacy and safety of Nusinersen for spinal muscular atrophy types 1, 2, 3: a systematic review of the current evidence

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Spinal muscular atrophy (SMA) is a severe genetic neuromuscular disorder characterized by muscle atrophy and weakness due to motor neuron loss. It results from mutations in the SMN1 gene, leading to insufficient SMN protein, which is essential
Somaia Daghriri, Yara A. Alorfi, Rasil Sulaiman Alayed, Wid F. Altaf, Ghaida E. Alharbi, Hisham Alsulami, Raghad Alkhalifah, Omar Alzahrani, Abdulrahman Softah   +8 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers [PDF]

, 2017
Spinal muscular atrophy (SMA) is a neurodegenerative disorder that results from mutations in the SMN1 gene, leading to survival motor neuron (SMN) protein deficiency.
Elliot A. Androphy, Cherry, Jonathan J., Glicksman, Marcie A., Fiejtek, Dawid K., Christian L. Lorson, Calder, Alyssa N., Hodgetts, Kevin J., Cuny, Gregory D., Lorson, Christian L., Alyssa N. Calder, Xing, Xuechao, Sungwoon Choi, Marcie A. Glicksman, Xuechao Xing, Quist, Kevin M., Kevin M. Quist, Choi, Sungwoon, Eliza H. Miller, Kevin J. Hodgetts, Androphy, Elliot A., Li, Hongxia, Anderson, Kierstyn P., Dawid K. Fiejtek, Anne Rietz, Jonathan J. Cherry, Miller, Eliza H., Kierstyn P. Anderson, Gregory D. Cuny, Rietz, Anne, Hongxia Li   +29 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Survival motor neuron protein participates in mouse germ cell development and spermatogonium maintenance

, 2022
The defective human survival motor neuron 1 (SMN1) gene leads to spinal muscular atrophy (SMA), the most common genetic cause of infant mortality. We previously reported that loss of SMN results in rapid differentiation of Drosophila germline stem cells ...
Lin, TY, Hsieh-Li, HM, Sung, LY, Xu, J, Liu, JL, Lu, CH, Hwu, YM, Hsu, J, Chang, WF   +8 more
core   +1 more source