Results 61 to 70 of about 561,319 (304)

Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature [PDF]

, 2017
The concept that solid tumors are maintained by a productive interplay between neoplastic and non-neoplastic elements has gained traction with the demonstration that stromal fibroblasts and immune system cells dictate cancer development and progression ...
Bush, Erin C, Gutmann, David H, Ma, Yu, Pan, Yuan, Sims, Peter A, Solga, Anne C, Toonen, Joseph A   +6 more
core   +2 more sources

Nonparametric Predictive Inference for Discrete Lifetime Data

Mathematics
This paper presents nonparametric predictive inference for discrete lifetime data. While lifetimes are mostly treated as continuous random variables in statistics, there are scenarios where time observations are recorded as discrete values, for example ...
Frank P. A. Coolen, Tahani Coolen-Maturi, Ali M. Y. Mahnashi   +2 more
doaj   +1 more source

Development and validation of a RNA binding protein gene pair-associated prognostic signature for prediction of overall survival in hepatocellular carcinoma

BioMedical Engineering OnLine, 2020
Background Increasing evidence has demonstrated the correlation between hepatocellular carcinoma (HCC) prognosis and RNA binding proteins (RBPs) dysregulation.
Chunmiao Kang, Xuanhui Jia, Hongsheng Liu   +2 more
doaj   +1 more source

A seven-gene prognostic signature predicts overall survival of patients with lung adenocarcinoma (LUAD)

Cancer Cell International, 2021
Background Lung adenocarcinoma (LUAD) is one of the most common types in the world with a high mortality rate. Despite advances in treatment strategies, the overall survival (OS) remains short.
Aisha Al-Dherasi, Qi-Tian Huang, Yuwei Liao, Sultan Al-Mosaib, Rulin Hua, Yichen Wang, Ying Yu, Yu Zhang, Xuehong Zhang, Chao Huang, Haithm Mousa, Dongcen Ge, Sufiyan Sufiyan, Wanting Bai, Ruimei Liu, Yanyan Shao, Yulong Li, Jingkai Zhang, Leming Shi, Dekang Lv, Zhiguang Li, Quentin Liu   +21 more
doaj   +1 more source

Impact of depth of response on survival in patients treated with cobimetinib ± vemurafenib: pooled analysis of BRIM-2, BRIM-3, BRIM-7 and coBRIM. [PDF]

, 2019
BackgroundThis pooled analysis investigated the prognostic value of depth of response in two cohorts of patients with BRAFV600-mutated metastatic melanoma treated with vemurafenib or cobimetinib plus vemurafenib.MethodsThe data were pooled from BRIM-2 ...
Ascierto, Paolo A, Dréno, Brigitte, Flaherty, Keith T, Hauschild, Axel, Larkin, James, Lewis, Karl D, McArthur, Grant A, McKenna, Edward, Mun, Yong, Ribas, Antoni, Wongchenko, Matthew, Yan, Yibing, Zhu, Qian   +12 more
core   +2 more sources

Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer [PDF]

British Journal of Cancer, 2019
Metastatic colorectal cancer (mCRC) is a highly heterogeneous disease from a clinical, molecular, and immunological perspective. Current predictive models rely primarily in tissue based genetic analysis, which not always correlate with inflammatory response.
Varkaris, Andreas, Katsiampoura, Anastasia, Davis, Jennifer S., Shah, Neeraj, Lam, Michael, Frias, Rosa Lizeth, Ivan, Cristina, Shimizu, Masayoshi, Morris, Jeffrey, Menter, David, Overman, Michael, Tran, Hai, Heymach, John, Chun, Yun Shin, Vauthey, Jean-Nicolas, Calin, George, Kopetz, Scott   +16 more
openaire   +2 more sources

Twenty Metabolic Genes Based Signature Predicts Survival of Glioma Patients [PDF]

Journal of Cancer, 2020
Background: Glioma, caused by carcinogenesis of brain and spinal glial cells, is the most common primary malignant brain tumor. To find the important indicator for glioma prognosis is still a challenge and the metabolic alteration of glioma has been frequently reported recently.
Xu, Wenfang, Liu, Zhenhao, Ren, He, Peng, Xueqing, Wu, Aoshen, Ma, Duan, Liu, Gang, Liu, Lei   +7 more
openaire   +2 more sources

Development and internal validation of a nine-lncRNA prognostic signature for prediction of overall survival in colorectal cancer patients [PDF]

PeerJ, 2018
Background Colorectal cancer remains a serious public health problem due to the poor prognosis. In the present study, we attempted to develop and validate a prognostic signature to predict the individual mortality risk in colorectal cancer patients ...
Zhiqiao Zhang, Qingbo Liu, Peng Wang, Jing Li, Tingshan He, Yanling Ouyang, Yiyan Huang, Weidong Wang   +7 more
doaj   +2 more sources

Acircadian rhythm-related gene signature for predicting survival and drug response in HNSC

Frontiers in Immunology, 2022
Head and neck squamous cell carcinoma (HNSC) represents one of the most common malignant carcinomas worldwide. Because the 5-year survival rate of patients with HNSC is poor, it is necessary to develop an effective signature for predicting the risk of ...
Chuan Zhang, Dan Dang, Hongrui Wang, Shuyou Shi, Jiayu Dai, Ming Yang   +5 more
doaj   +1 more source

An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes. [PDF]

, 2013
BACKGROUND: Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are heterogeneous with respect to biological behaviour and prognosis. As angiogenesis is a renowned pathogenic hallmark as well as a therapeutic target, we aimed to investigate the ...
A Couvelard, A Giatromanolaki, A Rinke, AM Marion-Audibert, AT Dimou, B Terris, D Hanahan, D J Pinato, D O’Toole, DC Metz, DJ Pinato, DJ Pinato, E Raymond, EP Hui, F Panzuto, G Kloppel, HS Kim, I Albrecht, IM Modlin, J LeCouter, J Strosberg, J Zhang, JC Yao, JT Chi, JY Scoazec, K Hirabayashi, K Meeran, K Villaume, M Dal Monte, M Perigny, M Ruscica, MA Maynard, N Martin, N Ngo, P Kuiper, R Dina, R Katoh, R Mentlein, R Ramachandran, R Sharma, S Ezziddin, S T K Toussi, T M Tan, VD Corleto, Y Arvidsson, Y Seo, Y Takahashi, YC Patel   +47 more
core   +2 more sources