Results 81 to 90 of about 561,319 (304)

Integrative Analysis of DNA Methylation and Gene Expression Identify a Three-Gene Signature for Predicting Prognosis in Lower-Grade Gliomas

Cellular Physiology and Biochemistry, 2018
Background/Aims: In the current study, we performed an integrated analysis of genome-wide methylation and gene expression data to find novel prognostic genes for lower-grade gliomas (LGGs).
Wen-Jing Zeng, Yong-Long Yang, Zheng-Zheng Liu, Zhi-Peng Wen, Yan-Hong Chen, Xiao-Lei Hu, Quan Cheng, Jian Xiao, Jie Zhao, Xiao-Ping Chen   +9 more
doaj   +1 more source

Identification of an eight-gene signature for survival prediction for patients with hepatocellular carcinoma based on integrated bioinformatics analysis [PDF]

PeerJ, 2019
Background Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related death worldwide. Despite recent advances in imaging techniques and therapeutic intervention for HCC, the low overall 5-year survival rate of HCC patients ...
Guo-jie Qiao, Liang Chen, Jin-cai Wu, Zhou-ri Li   +3 more
doaj   +2 more sources

A Ferroptosis-Related Gene Signature Identified as a Novel Prognostic Biomarker for Colon Cancer

Frontiers in Genetics, 2021
BackgroundColon cancer (CC) is a common gastrointestinal malignant tumor with high heterogeneity in clinical behavior and response to treatment, making individualized survival prediction challenging.
Xin Qi, Rui Wang, Yuxin Lin, Donghui Yan, Jiachen Zuo, Jiajia Chen, Bairong Shen   +6 more
doaj   +1 more source

A Robust Gene Expression Prognostic Signature for Overall Survival in High-Grade Serous Ovarian Cancer. [PDF]

, 2019
The objective of this research was to develop a robust gene expression-based prognostic signature and scoring system for predicting overall survival (OS) of patients with high-grade serous ovarian cancer (HGSOC).
Hang, Bo, Jin, Yu-Lan, Mao, Jian-Hua, Snijders, Antoine M, Wang, Pin, Xiong, Guang-Wu, Yang, Shao-Min, Zhang, Xiao-Wei, Zhao, Yue   +8 more
core  

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Oncogenic Pathway Signatures and Survival Outcome

, 2012
Recent microarray technology and bioinformatics have shown the ability of analysing oncogenic cellular signalling pathways based upon gene signatures in cancers. (Bild et al., 2006; Dressman et al., 2007; Gatza et al., 2010) Epithelial ovarian cancer (EOC) is the most important cause of mortality among gynaecological cancers.
Trinh, Xuan Bich, Dam, Peter A. Van, Dirix, Luc Y., Laere, Steven J. van, Tjalma, Wiebren A. A.   +4 more
openaire   +3 more sources

A novel microRNA signature predicts survival in stomach adenocarcinoma

Oncotarget, 2017
Recent microRNA (miRNA) expression profiling studies suggest the clinical use of miRNAs as potential prognostic biomarkers in various malignancies. In this study, aiming to identify microRNAs with prognostic value for overall survival (OS) in stomach adenocarcinoma (STAD) patients, we analyzed the miRNA expression profiles and the associated clinical ...
Ding, Bowen, Gao, Xujie, Li, Hui, Liu, Liren, Hao, Xishan   +4 more
openaire   +3 more sources

Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer [PDF]

, 2017
Background: A 70-gene signature was previously shown to have prognostic value in patients with node-negative breast cancer. Our goal was to validate the signature in an independent group of patients.
Amakrane, Mohamed, Bergh, Jonas, Bogaerts, Jan, Buyse, Marc, Cardoso, Fatima, Delorenzi, Mauro, Ellis, Paul, Floore, Arno, Glas, Annuska M., Harris, Adrian, Lidereau, Rosette, Loi, Sherene, Piccart, Martine J., Piette, Fanny, Rutgers, Emiel, Saghatchian d'Assignies, Mahasti, Sotiriou, Christos, Therasse, Patrick, van't Veer, Laura, Viale, Giuseppe   +19 more
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

An inflammatory cytokine signature predicts COVID-19 severity and survival [PDF]

Nature Medicine, 2020
Several studies have revealed that the hyper-inflammatory response induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major cause of disease severity and death. However, predictive biomarkers of pathogenic inflammation to help guide targetable immune pathways are critically lacking.
Del Valle, Diane Marie, Kim-Schulze, Seunghee, Huang, Hsin-Hui, Beckmann, Noam D., Nirenberg, Sharon, Wang, Bo, Lavin, Yonit, Swartz, Talia H., Madduri, Deepu, Stock, Aryeh, Marron, Thomas U., Xie, Hui, Patel, Manishkumar, Tuballes, Kevin, Van Oekelen, Oliver, Rahman, Adeeb, Kovatch, Patricia, Aberg, Judith A., Schadt, Eric, Jagannath, Sundar, Mazumdar, Madhu, Charney, Alexander W., Firpo-Betancourt, Adolfo, Mendu, Damodara Rao, Jhang, Jeffrey, Reich, David, Sigel, Keith, Cordon-Cardo, Carlos, Feldmann, Marc, Parekh, Samir, Merad, Miriam, Gnjatic, Sacha   +31 more
openaire   +2 more sources