Results 101 to 110 of about 908,839 (305)

“And Then One Day, Me and My Husband, We Learned How to Cross the Street”: Hazara Women’s Experiences in Sydney and Yearnings for ‘Home’

Genealogy
As numbers of displaced people throughout the world steadily increase with the rise in global conflicts, many Western nations, including Australia, increasingly thwart asylum-seeking and place harsh restrictions on entry.
Rimple Mehta, Linda Briskman, Michel Edenborough, Fran Gale, Samantha Tom Cherian, Mohammad Arif Nabizadah, Jasmina Bajraktarevic-Hayward, Asma Naurozi   +7 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Effectiveness of rehabilitation dose heterogeneity for improving functional outcomes of patients with acute stroke: a nationwide observational study

Scientific Reports
To examine heterogeneity in the impact of increased early rehabilitation intensity and to identify which ischemic stroke patients benefit most. We analysed 39,140 propensity score-matched ischemic stroke patients using Diagnosis Procedure Combination ...
Takuaki Tani, Masashi Kanai, Masatoshi Kamada, Kazushige Ide, Kiyohide Fushimi   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Initial calf circumference predicts poor disability outcomes in patients with stroke

The Journal of Nutrition, Health and Aging
Background: Calf circumference (CC), which is easy to measure and noninvasive, may be a predictor of functional outcome in patients with acute stroke. However, the association between CC and long-term functional outcome is unclear.
Yoichi Sato, Takafumi Abe, Yosuke Kimura, Shu Tanaka, Kazuki Okuda, Ayaki Shirahata, Kenta Yamamoto, Masafumi Nozoe   +7 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Deinstitutionalization as Reparative Justice: A Commentary on the Guidelines on Deinstitutionalization, including in Emergencies

Laws
In this paper, I argue that the Committee on the Rights of Persons with Disabilities Guidelines on Deinstitutionalization, Including in Emergencies function as an instrument and template for reparative justice towards persons still in institutions and ...
Tina Minkowitz
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Remembering the Holocaust with Rosalie Franks [PDF]

, 2015
From her work on Steven Spielberg’s Holocaust survivors project to her RWU classroom, adjunct professor instills the importance of human rights and social ...
Rodrigues, Jill
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source