Results 101 to 110 of about 2,628,441 (278)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
BMC PsychiatryBackground Recovery from severe mental illness, including psychosis has been described as a personal and unique process, but it rarely is a journey undertaken without profound influences of significant others (family, mental health professionals ...
Thijs J. Burger +13 more
doaj +1 more source
Genetically susceptible subgroups. [PDF]
Environmental Health Perspectives, 1978 In establishing "safe" standards for all with respect to environmental carcinogenesis, one must consider the heterogeneity of man. Although cancer is considered primarily an environmental disease, there is a wide range of geneticqnvironmental interaction which ultimately influences the development of malignant disease.
openaire +2 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Fidelity susceptibility, scaling, and universality in quantum critical phenomena
, 2007 We study fidelity susceptibility in one-dimensional asymmetric Hubbard model, and show that the fidelity susceptibility can be used to identify the universality class of the quantum phase transitions in this model.
Hai-Qing Lin +7 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Frontiers in Microbiology, 2017 It is known that an ineffective antibiotic treatment can induce morphological shifts in uropathogenic Escherichia coli (UPEC) but the virulence properties during these shifts remain to be studied.
Isak Demirel +8 more
doaj +1 more source
On the confinement of spinons in the $CP^{M-1}$ model
, 1995 We use the $1/M$ expansion for the $CP^{M-1}$ model to study the long-distance behaviour of the staggered spin susceptibility in the commensurate, two-dimensional quantum antiferromagnet at finite temperature.
Chubukov, Andrey V., Starykh, Oleg A.
core +2 more sources