Results 101 to 110 of about 2,840,578 (328)

The Behavior of Epidemics under Bounded Susceptibility

, 2014
We investigate the sensitivity of epidemic behavior to a bounded susceptibility constraint -- susceptible nodes are infected by their neighbors via the regular SI/SIS dynamics, but subject to a cap on the infection rate. Such a constraint is motivated by
Banerjee, Siddhartha, Krishnasamy, Subhashini, Shakkottai, Sanjay   +2 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Perspective matters in recovery: the views of persons with severe mental illness, family and mental health professionals on collaboration during recovery, a qualitative study

BMC Psychiatry
Background Recovery from severe mental illness, including psychosis has been described as a personal and unique process, but it rarely is a journey undertaken without profound influences of significant others (family, mental health professionals ...
Thijs J. Burger, Robin M. van Eck, Marjolein Lachmeijer, Kimriek R. G. de Wilde-Schutten, Mette Lansen, Carola van Alphen, Niek van Haasteren, Karin Groen, Frederike Schirmbeck, Astrid Vellinga, Martijn J. Kikkert, Jack Dekker, Lieuwe de Haan, Mariken B. de Koning   +13 more
doaj   +1 more source

Genetically susceptible subgroups. [PDF]

Environmental Health Perspectives, 1978
In establishing "safe" standards for all with respect to environmental carcinogenesis, one must consider the heterogeneity of man. Although cancer is considered primarily an environmental disease, there is a wide range of geneticqnvironmental interaction which ultimately influences the development of malignant disease.
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Landslide susceptibility estimation by random forests technique: sensitivity and scaling issues [PDF]

, 2013
Filippo Catani, Daniela Lagomarsino, Samuele Segoni, Veronica Tofani   +3 more
openalex   +1 more source

A Generalized Ginzburg-Landau Approach to Second Harmonic Generation

, 1999
We develop a generalized Ginzburg-Landau theory for second harmonic generation (SHG) in magnets by expanding the free energy in terms of the order parameter in the magnetic phase and the susceptibility tensor in the corresponding high-temperature phase ...
Gros, C., Sa, Debanand, Valenti, R.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Critical exponents and the correlation length in the charge exchange manganite spin glass Eu_{0.5}Ba_{0.5}MnO_{3}

, 2005
The critical regime of the charge exchange (CE) manganite spin glass Eu_{0.5}Ba_{0.5}MnO_{3} is investigated using linear and non linear magnetic susceptibility and the divergence of the third ordered susceptibility (chi{_3}) signifying the onset of a ...
A. K. Nigam, C. N. R. Rao, E. Dagotto, H. E. Stanley, J. A. Mydosh, Sunil Nair, Y. Tokura   +6 more
core   +1 more source