Results 101 to 110 of about 1,629,436 (316)

Perspective matters in recovery: the views of persons with severe mental illness, family and mental health professionals on collaboration during recovery, a qualitative study

BMC Psychiatry
Background Recovery from severe mental illness, including psychosis has been described as a personal and unique process, but it rarely is a journey undertaken without profound influences of significant others (family, mental health professionals ...
Thijs J. Burger, Robin M. van Eck, Marjolein Lachmeijer, Kimriek R. G. de Wilde-Schutten, Mette Lansen, Carola van Alphen, Niek van Haasteren, Karin Groen, Frederike Schirmbeck, Astrid Vellinga, Martijn J. Kikkert, Jack Dekker, Lieuwe de Haan, Mariken B. de Koning   +13 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility. [PDF]

, 2013
The BLK and CD40 loci have been associated with Kawasaki disease (KD) in two genome-wide association studies (GWAS) conducted in a Taiwanese population of Han Chinese ancestry (Taiwanese) and in Japanese cohorts.
Yi-Min Liu (230875), Lee, Yi-Ching, Jong-Keuk Lee (142576), Chen, Y.-T., Liu, YM, Wu, J.-Y., Lee, Y.-C., Tsai, FJ, Martin L Hibberd, Li-Ching Chang, Taiwan Kawasaki Disease Genetics Consortium, Chang, Chia-Jung, Khor, C.C., Liu, Y.-M., Jane C Burns, Chia-Jung Chang (452299), Ho-Chang Kuo (156547), Li-Ching Chang (230873), Michael Levin (21355), Hibberd, Martin L., Burns, Jane C., Burns, JC, Fuu-Jen Tsai, Gi Young Jang, Chang, J.-S., Burgner, D., Burgner, D, Kuijpers, Taco, Chen, Ying-Ju, Chang, C.-J., Levin, M, Hong, YM, Chen, CH, Davila, Sonia, Wu, JY, Lee, YC, Fuu-Jen Tsai (230856), Chen, Chien-Hsiun, Levin, M., Chien-Hsiun Chen, Chiea Chuen Khor (306345), Jang, G.Y., Sonia Davila, Chen, S.-P., Jong-Keuk Lee, Ko, T.-M., Chen, SP, Burgner, David, Davila, S, Ko, Tai-Ming, Yi-Min Liu, Jane C. Burns (268128), Wu, Jer-Yuarn, Jane C. Burns, Ko, TM, Kuo, HC, Chang, L.-C., Chen, C.-H., Hibberd, ML, Chang, JS, Taco Kuijpers (452304), Lee, Jong-Keuk, Burns, J.C., Jeng-Sheng Chang, Hong, Y.M., Kuijpers, T, Young Mi Hong, Hibberd, Martin L, Yuan-Tsong Chen (19419), Jer-Yuarn Wu (92059), Jang, GY, Kuo, H.-C., Gi Young Jang (452303), Chen, YJ, Liu, Yi-Min, Chang, CJ, Martin L. Hibberd, Ho-Chang Kuo, Chen, Yuan-Tsong, Chen, YT, Tai-Ming Ko, Tai-Ming Ko (452301), Yi-Ching Lee, Chiea Chuen Khor, Chang, Jeng-Sheng, Korean Kawasaki Disease Genetics Consortium, Yi-Ching Lee (214372), Shih-Ping Chen, Burns, Jane C, International Kawasaki Disease Genetics Consortium, Jer-Yuarn Wu, Ying-Ju Chen (296144), Taco Kuijpers, Levin, Michael, Khor, CC, Chang, LC, Hibberd, M.L., Kuijpers, T., Young Mi Hong (452302), Chien-Hsiun Chen (28863), Chen, Y.-J., Sonia Davila (268093), Jang, Gi Young, Yuan-Tsong Chen, Ying-Ju Chen, Chia-Jung Chang, Hong, Young Mi, Chang, Li-Ching, Kuo, Ho-Chang, Lee, J.-K., Khor, Chiea Chuen, Tsai, F.-J., Michael Levin, David Burgner, Davila, S., Tsai, Fuu-Jen, Shih-Ping Chen (452300), Chen, Shih-Ping, Martin L. Hibberd (167212), David Burgner (268086), Lee, JK, Jeng-Sheng Chang (230858)   +121 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Effects of white matter microstructure on phase and susceptibility maps [PDF]

Purpose: To investigate the effects on quantitative susceptibility mapping (QSM) and susceptibility tensor imaging (STI) of the frequency variation produced by the microstructure of white matter (WM).Methods: The frequency offsets in a WM tissue sample ...
Wharton, Samuel, Bowtell, Richard W.
core   +1 more source

Susceptibility Status of Malaria Vectors to Insecticides Commonly used for Malaria Control in Tanzania. [PDF]

, 2012
The aim of the study was to monitor the insecticide susceptibility status of malaria vectors in 12 sentinel districts of Tanzania. WHO standard methods were used to detect knock-down and mortality in the wild female Anopheles mosquitoes collected in ...
Njau, Ritha, Kabula, Bilali, Matowo, Johnson, Sindato, Calvin, Kitau, Jovin, Kisinza, William, Tungu, Patrick, Emidi, Basiliana, Masue, Denis, Minja, Jubilate, Mosha, Franklin, Msangi, Shandala, Mweya, Clement, Malima, Robert, Magesa, Stephen   +14 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Incorporating geomorphological analyses to identify potential criticalities for flood susceptibility in Romagna Plain [PDF]

openEmilia-Romagna, Italy, suffered significant floods in May 2023 consequently, of torrential rains following a protracted drought. Levees, major flood defense infrastructure, were damaged yet played an important role throughout the event, illustrating ...
KHAN, MUHAMMAD UZAIR
core