Results 71 to 80 of about 1,629,436 (316)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Identification of autophagy receptors for the Crohn’s disease-associated adherent-invasive Escherichia coli

Frontiers in Cellular and Infection Microbiology
IntroductionCrohn’s disease (CD) is a chronic inflammatory bowel disease, of which the etiology involves genetic, environmental and microbial factors.
Alison Da Silva, Guillaume Dalmasso, Anaïs Larabi, My Hanh Thi Hoang, My Hanh Thi Hoang, Elisabeth Billard, Nicolas Barnich, Hang Thi Thu Nguyen   +7 more
doaj   +1 more source

Macrophages Inability to Mediate Adherent-Invasive E. coli Replication is Linked to Autophagy in Crohn’s Disease Patients

Cells, 2019
The macrophages from Crohn’s Disease (CD) patients are defective to control the replication of CD-associated adherent-invasive E. coli (AIEC). We aimed to identify the host factors associated with AIEC replication focusing on polymorphisms related ...
Anthony Buisson, Clara Douadi, Lemlih Ouchchane, Marion Goutte, Jean-Pierre Hugot, Anaëlle Dubois, Régine Minet-Quinard, Damien Bouvier, Gilles Bommelaer, Emilie Vazeille, Nicolas Barnich   +10 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Susceptibility test on Aspergillus Fumigatus

, 2020
Aspergillus fumigatus is the most common and pathogenic species of Aspergillus.Aspergillus fumigatus usually infects immunocompromised patients, in these patients it has a comparatively high death rate when causing IPA.
Haider, Syeda Masooma
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Candida Glabrata Fungaemia in a Tertiary Centre in Taiwan: Antifungal Susceptibility and Outcomes

, 2011
The proportion of non-albicans candidaemia has increased during recent decades, especially Candida glabrata. We evaluated the antifungal susceptibility, clinical features and outcome of C. glabrata fungaemia treated in a tertiary centre in Taiwan.
RUAN, SHENG-YUAN;HUANG, YU-TSUNG;CHU, CHEN-CHEN;YU, CHONG-JEN;HSUEH, PO-REN, 阮聖元;黃昱璁;朱蓁蓁;余忠仁;薛博仁   +1 more
core   +1 more source

Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo. [PDF]

, 2010
BACKGROUND: Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases.
Bennett, DC, Jin, Y., Weetman, A.P., van Geel, Nanja, Gawkrodger, DJ, Hutton, SM, Jouary, T, Bennett, D.C., Sufit, AJ, Kemp, E.H., Gowan, K, Picardo, M, Mailloux, CM, Fain, PR, Hutton, S.M., Weetman, AP, Taïeb, A., Spritz, RA, Lambert, J., Kemp, EH, Leone, G., Spritz, R.A., Overbeck, A., Amadi-Myers, A, van Geel, NanjaGE34UZGent0019989522538010015029510000-0002-3249-8195FB35B7E6-F0ED-11E1-A9DE-61C894A0A6B4, Birlea, S.A., Amadi-Myers, A., Wallace, MR, Wallace, M.R., Riccardi, SL, Birlea, SA, Leone, G, Jouary, T., Jin, Y, van Geel, N, Gowan, K., van Geel, N., Mailloux, C.M., Overbeck, A, McCormack, W.T., Picardo, M., Riccardi, S.L., Fain, P.R., Ezzedine, K., Lambert, J, Ezzedine, K, Sufit, A.J., Lambert, JoGE34UZGent8010010521050000-0001-5303-9310F4F50E9A-F0ED-11E1-A9DE-61C894A0A6B4, Holland, PJ, McCormack, WT, Sufit, AJD, Lambert, Jo, Holland, P.J., Gawkrodger, D.J., Taïeb, A   +54 more
core   +1 more source

Targeting metastatic breast cancer: problems and potential [v1; ref status: indexed, http://f1000r.es/534]

F1000Research, 2015
Breast cancer is one of the leading causes of cancer-related mortality of women in the United States. Since the majority of cancer deaths are due to metastases rather than the primary tumor, a better understanding of the biological mechanisms that lead ...
Sarah Deasy, Karol Szczepanek, Kent Hunter   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source