Results 101 to 110 of about 4,800,471 (257)

Collaborative assessment and the assessment of collaboration

, 2012
Anecdotal evidence suggests that while learning through group work and evaluation through group assessment are common in primary schools, this trend tapers in secondary, and virtually disappears in the latter years of secondary school and through into ...
McAlpine, Mhairi
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Societal Indicators for the National Climate Assessment

, 2011
A report made pertaining to the workshop made by the Climate Change Impacts and Responses: Societal Indicators for the National Climate Assessment workshop.
National Climate Assessment
core  

Susceptibility evaluation of valley debris flow based on dual-channel network with fusion attention mechanism

Zhongguo dizhi zaihai yu fangzhi xuebao
In addressing the issue of debris flow disaster assessment, this paper proposes a novel lightweight convolutional neural network model, the Dual-Channel Fusion Attention Mechanism Network (DCFAMNet), designed to rapidly identifying the susceptibility of ...
Yumeng LUO, Baoyun WANG, Ruohao YUAN, Xu WANG, Cunxi LIU, Kuayue CHEN   +5 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

e-Assessment: past, present and future

, 2014
The goal of this paper is to provide an overview of the evolution of electronic assessment, or e-assessment, within the context of a developing e-pedagogy by investigating the changes occurring over time in the ways e-pedagogy is described.
Hench, Thomas
core  

The Influence of Non-Landslide Sample Selection Methods on Landslide Susceptibility Prediction

Land
Non-landslide sample selection is critical in landslide susceptibility modeling due to its direct impact on model accuracy and reliability. This study compares three sample selection strategies: whole-region random selection, landslide buffer zone ...
Yu Fu, Zhihao Fan, Xiangzhi Li, Pengyu Wang, Xiaoyue Sun, Yu Ren, Wengeng Cao   +6 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source