Results 101 to 110 of about 720,195 (285)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Morus alba L. Cell Cultures as Sources of Antioxidant and Anti-Inflammatory Stilbenoids for Food Supplement Development

Molecules
Morus alba L. (Moraceae), white mulberry, is an ancient, well-known source of several compounds with potent biological activities and beneficial effects on human health.
Vanessa Dalla Costa, Anna Piovan, Paola Brun, Raffaella Filippini   +3 more
doaj   +1 more source

Electrophoretic-deposited HAP nano-layer as a QCM-D sensor coating: effects of suspension concentration and electric-field strength

Biosurface and Biotribology, 2018
This study investigates the fabrication of hydroxyapatite (HAP) nano-coating on a gold–quartz crystal sensor used for quartz crystal microbalance with dissipation (QCM-D) measurement using an electrophoretic deposition technique.
Liang Zheng, Wei Gong, Yue Tang, Genlei Ma, Jing Zheng, Shi-zhe Chen, Wei-hua Li   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Comparison of Integral Equation Formulations for Stokesian Particulate Flow Simulations

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
Particulate Stokesian flows describe the hydrodynamics of rigid or deformable particles within Stokes flows, where viscous forces dominate over inertial effects.
Gökberk Kabacaoğlu
doaj   +1 more source

Viscoelasticity and shear-thinning effects on bio-polymer solution and suspended particle behaviours under oscillatory curve Couette flow conditions

Biosurface and Biotribology, 2018
Formation of wear particles within total hip replacement is one of the main causes of its failure. In addition to improving the lubrication and wear resistance of materials used as bearing surfaces, understanding of wear particle distribution patterns ...
Alaleh Safari, Nazanin Emami, Michel Jose Cervantes   +2 more
doaj   +1 more source

The electrorheology of suspensions consisting of Na-Fluorohectorite synthetic clay particles in silicon oil

, 2010
Under application of an electric field greater than a triggering electric field $E_c \sim 0.4$ kV/mm, suspensions obtained by dispersing particles of the synthetic clay fluoro-hectorite in a silicon oil, aggregate into chain- and/or column-like ...
B. Schjelderupsen, Felici N., Hao T., J. O. Fossum, K. P. S. Parmar, Macosko C., Méheust Y., Y. Méheust   +7 more
core   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Tribological behaviour of copper oxide nanoparticle suspension [PDF]

, 2008
This work presents and discusses the tribological behaviour of nanoparticle suspensions in a polyalphaolefin (PAO6). CuO nanoparticles were separately dispersed at 0.5, 1.0 and 2.0% wt. in PAO6 using an ultrasonic probe for 2 minutes.
Fernandez, J.E., Hernandez Battez, Antolin, Viesca Rodriguez, J.L.   +2 more
core