Results 81 to 90 of about 414,542 (317)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Volume fraction variations and dilation in colloids and granulars
, 2009 Discusses the importance of spatial and temporal variations in particle volume fraction to understanding the force response of concentrated colloidal suspensions and granular ...
Haw, M.D.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Children, 2019 Compounding pharmacy has an important role to play in the field of pediatric medicine. These specialized pharmacies can offer solutions to the unique patient needs that arise in the pediatric population.
Tricia Heitman +2 more
doaj +1 more source
Effects of Particles Diffusion on Membrane Filters Performance
Fluids, 2020 Membrane filtration fouling is a very complex process and is determined by many properties such as the membrane internal morphology, membrane pore structure, flow rate and contaminant properties. In a very slow filtration process or during the late stage
Shi Yue Liu, Zhengyi Chen, Pejman Sanaei
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Improved numerical methods in reliability analysis of suspension roof joints
Инженерно-строительный журнал, 2016 Modern structures require more complex designs. There is an increased need for accurate approaches to assessing uncertainties in loads, geometry, material properties, and operational environments.
I.N. Priadko +4 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Surface-wave instability without inertia in shear-thickening suspensions
, 2020 International audienceRecent simulations and experiments have shown that shear-thickening of dense particle suspensions corresponds to a frictional transition. Based on this understanding, nonmonotonic rheological laws have been proposed and successfully
Lhuissier, Henri +3 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source