Results 71 to 80 of about 720,195 (285)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Caracterización y preparación de ceniza volante para su uso como recubrimientos cerámicos sobre substratos metálicos

Boletín de la Sociedad Española de Cerámica y Vidrio, 2008
Fly ash samples were characterized by atomic absorption, plasma spectroscopy, DTA/TGA, SEM/EDS, XRD and laser diffraction in order to obtain fly ash coatings on stainless steel substrates by electrophoretic deposition.
Chávez, A., Vargas, G., Almanza, J. M.
doaj  

Investigation of the dynamical slowing down process in soft glassy colloidal suspensions: comparisons with supercooled liquids

, 2013
The primary and secondary relaxation timescales of aging colloidal suspensions of Laponite are estimated from intensity autocorrelation functions obtained in dynamic light scattering (DLS) experiments.
Bandyopadhyay, Ranjini, Joshi, Yogesh M., Saha, Debasish   +2 more
core   +1 more source

Pendulum Mode Thermal Noise in Advanced Interferometers: A comparison of Fused Silica Fibers and Ribbons in the Presence of Surface Loss [PDF]

, 2000
The use of fused-silica ribbons as suspensions in gravitational wave interferometers can result in significant improvements in pendulum mode thermal noise.
Abramovici, Andri M. Gretarsson, Blair, Braginsky, Braginsky, Braginsky, Callen, Callen, Gianpietro Cagnoli, Giazotto, Gregory M. Harry, Gretarsson, Hillig, Jim Hough, Morley, Peter R. Saulson, Proctor, Rowan, Saulson, Sheila Rowan, Startin, Steven D. Penn, William J. Startin, Zener   +23 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Particle-scale statistical theory for hydrodynamically induced polar ordering in microswimmer suspensions

, 2018
Previous particle-based computer simulations have revealed a significantly more pronounced tendency of spontaneous global polar ordering in puller (contractile) microswimmer suspensions than in pusher (extensile) suspensions.
Hoell, Christian, Löwen, Hartmut, Menzel, Andreas M.   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Pressure drop of three-phase suspension flows (water-air-sand) in horizontal pipelines

Revista Técnica de la Facultad de Ingeniería, 2011
In this work we report experimental results and the mathematica1 model for the flow of three-phase suspensions (gas-liquid-solid) through horizontal pipes in a bench installation.
Filippo Pironti, Gabriel Pellegrino, Gluber Meza, Nelson Ramírez   +3 more
doaj  

Extensional viscosity of copper nanowire suspensions in an aqueous polymer solution

, 2015
Suspensions of copper nanowires are emerging as new electronic inks for next-generation flexible electronics. Using a novel surface acoustic wave driven extensional flow technique we are able to perform currently lacking analysis of these suspensions and
Cheng, Wenlong, Friend, James R., Jason, Naveen N., McDonnell, Amarin G., Prabhakar, Ranganathan, Yeo, Leslie Y.   +5 more
core   +1 more source