Results 71 to 80 of about 712,286 (285)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Silicon mirror suspensions for gravitational wave detectors [PDF]

, 2013
One of the most significant limits to the sensitivity of current, and future, long-baseline interferometric gravitational wave detectors is thermal displacement noise of the test masses and their suspensions.
Cumming, A.V., Cunningham, L., Hammond, G., Haughian, K., Hough, J., Kroker, S., Martin, I.W., Nawrodt, R., Rowan, S., Schwarz, C., van Veggel, A.A.   +10 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Steady Shear Rheology of Suspensions of Mixtures of Starch Nanoparticles and Cellulose Nanocrystals

Nanomaterials
The steady shear rheology of suspensions of mixtures of rod-shaped cellulose nanocrystals (NCC) and spherical starch nanoparticles (SNPs) was investigated experimentally over a broad range of NCC and SNP concentrations.
Hanie Alizadeh, Rajinder Pal
doaj   +1 more source

Rheological Interpretation of the Slump Test

Applied Rheology, 2002
We examine the validity of the slump test for predicting the yield stress of polymeric suspensions and mineral suspensions. First we propose a modification of this test: in order to make measurements on fluids with high yield stress (of the order of ...
Baudez Jean-Christophe, Chabot Frédéric, Coussot Philippe   +2 more
doaj   +1 more source

Clogging by sieving in microchannels: Application to the detection of contaminants in colloidal suspensions

, 2014
We report on a microfluidic method that allows measurement of a small concentration of large contaminants in suspensions of solid micrometer-scale particles.
Adeline Perro, Alban Sauret, Bruus H., Carman P. C., Coulson J. M., Emilie Dressaire, Emmanuel Villermaux, Erin C. Barney, Howard A. Stone   +8 more
core   +4 more sources

Pendulum Mode Thermal Noise in Advanced Interferometers: A comparison of Fused Silica Fibers and Ribbons in the Presence of Surface Loss [PDF]

, 2000
The use of fused-silica ribbons as suspensions in gravitational wave interferometers can result in significant improvements in pendulum mode thermal noise.
Abramovici, Andri M. Gretarsson, Blair, Braginsky, Braginsky, Braginsky, Callen, Callen, Gianpietro Cagnoli, Giazotto, Gregory M. Harry, Gretarsson, Hillig, Jim Hough, Morley, Peter R. Saulson, Proctor, Rowan, Saulson, Sheila Rowan, Startin, Steven D. Penn, William J. Startin, Zener   +23 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Invited Article: CO_2 laser production of fused silica fibers for use in interferometric gravitational wave detector mirror suspensions [PDF]

, 2011
In 2000 the first mirror suspensions to use a quasi-monolithic final stage were installed at the GEO600 detector site outside Hannover, pioneering the use of fused silica suspension fibers in long baseline interferometric detectors to reduce suspension ...
Barton, M. A., Bell, A., Cagnoli, G., Cantley, C. A., Crooks, D. R. M., Cumming, A., Grant, A., Hammond, G. D., Harry, G. M., Heptonstall, A., Hough, J., Jones, R., Kelley, D., Kumar, R., Martin, I. W., Robertson, N. A., Rowan, S., Strain, K. A., Tokmakov, K., van Veggel, M.   +19 more
core   +2 more sources