Results 101 to 110 of about 2,796,465 (333)

Assessment of Sustainability Value and Dignified Well-Being in Inclusive Product Lifecycles [PDF]

open access: yesarXiv
Sustainability is a concept mainly assessed by the features of a product that are considered as specific metrics for sustainability in an engineering context. However, sustainability is a comprehensive process for improvement in sustainable development that can be structured with the influence of inclusivity of empowered people.
arxiv  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

Sustainability in Debate

open access: yesSustentabilidade em Debate, 2011
Sustainability in Debate
doaj   +1 more source

A User Interface Study on Sustainable City Trip Recommendations [PDF]

open access: yesarXiv
The importance of promoting sustainable and environmentally responsible practices is becoming increasingly recognized in all domains, including tourism. The impact of tourism extends beyond its immediate stakeholders and affects passive participants such as the environment, local businesses, and residents.
arxiv  

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Hypoxia‐guided treatment planning for lung cancer with dose painting by numbers

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Tumor hypoxia significantly impacts the efficacy of radiotherapy. Recent developments in the technique of dose painting by numbers (DPBN) promise to improve the tumor control probability (TCP) in conventional radiotherapy for hypoxic cancer.
Yazhou Li   +6 more
wiley   +1 more source

Declaração de Fortaleza

open access: yesSustentabilidade em Debate, 2010
Declaração de ...
2010 International Conference on Climate Sustainability and Development in Semi-arid Regions
doaj  

A multi-model study to inform the United States’ 2035 NDC

open access: yesNature Communications
In 2025, countries are expected to submit a third round of nationally determined contributions (NDCs) that outline emission reduction goals for 2035.
Gokul Iyer   +12 more
doaj   +1 more source

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