Results 81 to 90 of about 2,796,465 (333)

The 4.2 ka event is not remarkable in the context of Holocene climate variability

open access: yesNature Communications
The “4.2 ka event” is a commonly described abrupt climate excursion that occurred about 4200 years ago. However, the extent to which this event is coherent across regional and larger scales is unclear.
Nicholas P. McKay   +11 more
doaj   +1 more source

MSPs for the SDGs – Assessing the collaborative governance architecture of multi-stakeholder partnerships for implementing the Sustainable Development Goals

open access: yesEarth System Governance, 2023
Multi-stakeholder partnerships (MSPs) involving a diverse set of actors are assumed to reduce implementation gaps of the 2030 Agenda and the Sustainable Development Goals (SDGs). While existing research suggests that MSPs can complement state-led efforts
Lisa-Maria Glass, Jens Newig, Simon Ruf
doaj  

Report on the NSF Workshop on Sustainable Computing for Sustainability (NSF WSCS 2024) [PDF]

open access: yesarXiv
This report documents the process that led to the NSF Workshop on "Sustainable Computing for Sustainability" held in April 2024 at NSF in Alexandria, VA, and reports on its findings. The workshop's primary goals were to (i) advance the development of research initiatives along the themes of both sustainable computing and computing for sustainability ...
arxiv  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Using Sustainability Impact Scores for Software Architecture Evaluation [PDF]

open access: yesarXiv
For future regulatory compliance, organizations must assess and report on the state of sustainability in terms of its impacts over time. Sustainability, being a multidimensional concern, is complex to quantify. This complexity further increases with the interdependencies of the quality concerns across different sustainability dimensions.
arxiv  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

High-ambition climate action in all sectors can achieve a 65% greenhouse gas emissions reduction in the United States by 2035

open access: yesnpj Climate Action
Under the next cycle of target setting under the Paris Agreement, countries will be updating and submitting new nationally determined contributions (NDCs) over the coming year.
Alicia Zhao   +12 more
doaj   +1 more source

Advancing a global transition to clean energy – the role of international cooperation

open access: yesEconomics: Journal Articles, 2019
International cooperation in support of a global energy transition is on the rise, and official development assistance (ODA) in the energy sector is increasingly being directed to renewable energy sources.
Quitzow Rainer   +4 more
doaj   +1 more source

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