Results 91 to 100 of about 220,364 (303)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The diverse socioeconomic contributions of wildlife ranching

Conservation Science and Practice
The expansion of wildlife ranching has been broadly linked to conservation benefits, job creation, and economic contributions. However, a more nuanced understanding of the socioeconomic contributions of wildlife ranching accounting for the enterprise ...
Candice Denner, Hayley S. Clements, Matthew F. Child, Alta De Vos   +3 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Negotiating informality and urban resilience: implications for equity

Ecology and Society
Informality is a distinguishing characteristic of cities in the Global South and is strongly associated with urban inequality. Yet, in pursuing resilience, urban resilience strategies and planning have yet to grapple with the role of informality in ...
Hallie Eakin, Johan Enqvist, Maike Hamann, Nadine Methner, Martha Nthambi Sibanda, Jade L Sullivan, Ernita van Wyk, Gina Ziervogel   +7 more
doaj   +1 more source

A grassroots sustainable energy niche? Reflections on community energy case studies [PDF]

, 2013
System changing innovations for sustainability transitions are proposed to emerge in radical innovative niches. ‘Strategic Niche Management’ theory predicts that niche level actors and networks will aggregate learning from local projects, distilling and ...
Hargreaves, Tom, Hielscher, Sabine, Martiskainen, Mari, Seyfang, Gill, Smith, Adrian   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Sustainability transitions in consumption-production systems. [PDF]

Proc Natl Acad Sci U S A, 2023
Geels FW, Kern F, Clark WC.
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Welcome home! Introducing SocSES: a society for inclusive and impactful social-ecological research

Ecology and Society
Underpinned by systemic thinking, social-ecological systems (SES) research has emerged as a critical field for addressing the challenges of the Anthropocene, marked by a cross-scale focus, inter- and transdisciplinary approaches, and a strong emphasis on
Alta de Vos, Allyson Quinlan, Reinette Biggs, Elena M Bennett, Berta Martín-López, Albert V Norström, Garry D Peterson, Michael Schoon, Craig R. Allen, Erik Andersson, Julia Baird, Patricia Balvanera, Marta Berbés-Blázquez, Fikret Berkes, Rafael Calderon-Contreras, Stephen R Carpenter, Antonio J. Castro, Graeme S. Cumming, Marianne Falardeau, W. Liebrecht Fick, Carl Folke, Elson Ian Nyl E Galang, Stefan Gelcich, Line J Gordon, Nancy B Grimm, Jacqueline Hamilton, Jennifer Hodbod, Chinwe Ifejika Speranza, Larissa Koch, Aleksandra Kosanic, Rafael Lembi, Bruno Locatelli, Katja Malmborg, Amanda Manyani, Morgan Mathisonslee, Anahi Ocampo-Melgar, Kinga Psiuk, Cibele Queiroz, Maraja Riechers, Lisen Schultz, Odirilwe Selomane, Kate Sherren, Marja Spierenburg, Micaela Trimble, Francis Turkelboom, Caroline Wallington   +45 more
doaj   +1 more source