Results 81 to 90 of about 24,963 (264)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Welcome home! Introducing SocSES: a society for inclusive and impactful social-ecological research

open access: yesEcology and Society
Underpinned by systemic thinking, social-ecological systems (SES) research has emerged as a critical field for addressing the challenges of the Anthropocene, marked by a cross-scale focus, inter- and transdisciplinary approaches, and a strong emphasis on
Alta de Vos   +45 more
doaj   +1 more source

AN ANALYSIS OF THE EXTENT TO WHICH INDUSTRY 4.0 HAS BEEN CONSIDERED IN SUSTAINABILITY OR SOCIO-TECHNICAL TRANSITIONS

open access: yesSouth African Journal of Industrial Engineering, 2019
A growing database of literature is geared towards the analysis and evaluation of Industry 4.0. One of the points of interest is the assessment of Industry 4.0 in the context of sustainability and sustainable development. However, there seems to be a gap
Asiimwe, M. M. , de Kock, I. H.
doaj   +1 more source

Ecology and the transition to sustainability [PDF]

open access: yesFrontiers in Ecology and the Environment, 2005
Jerry M. Melillo   +2 more
openaire   +2 more sources

Nutrition transition and food sustainability [PDF]

open access: yesProceedings of the Nutrition Society, 2014
The aim of the present paper is to review nutrition transition (NT) ongoing in low and middle income countries and the associated dietary changes. NT is accompanied by demographic and epidemiological transition associated with economic development and urbanisation.
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Mapping the diversity & transformative potential of approaches to sustainable just cities

open access: yesUrban Transformations
How can cities be more sustainable and just? This question has guided a process of synthesizing insights from previously funded research and innovation projects that deal with approaches tackling urban sustainability and justice. As part of this process,
Flor Avelino   +10 more
doaj   +1 more source

Understanding science-society interactions (SSI): diverse viewpoints from mountain biosphere reserves

open access: yesJournal of Integrative Environmental Sciences
Addressing global challenges necessitates innovative forms of knowledge production such as various forms of science-society interactions (SSI), increasingly endorsed by international initiatives like the UNESCO Man and the Biosphere (MAB) Programme and ...
Alexander Mitrofanenko   +5 more
doaj   +1 more source

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