Results 81 to 90 of about 213,310 (312)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Unique Opportunities of Island States to Transition to a Low-Carbon Mobility System [PDF]

, 2020
Small islands developing states (SIDS) contribute minuscule proportions to global greenhouse gas (GHG) emissions and energy consumption, but are highly exposed to climate change impacts, in particular to extreme weather events and sea-level rise. However,
Blechinger, Philipp, Creutzig, Felix, Soomauroo, Zakia   +2 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

COVID-19 impacts on school operations: a pushback on the attainment of SDG 4 in South Africa

Cogent Education
In May 2023, the World Health Organization declared that COVID-19 was no longer a public health emergency of international concern. However, this declaration does not remove severe negative impacts COVID-19 had on the education sector. This paper sets an
Godwell Nhamo, Lazarus Chapungu, Muchaiteyi Togo   +2 more
doaj   +1 more source

Behavioral Foundations of Sustainability Transitions [PDF]

, 2012
"Writings on sustainability transitions generally do not say much about the particularities of the behavior of individuals and organizations. This is somewhat surprising since an important problem which transition management needs to tackle is inertia or
Antal, Miklós, Gazheli, Ardjan, van den Bergh, Jeroen   +2 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Status quo of sustainable development goals localisation in Zimbabwean universities: Students perspectives and reflections

Sustainable Futures
This study examines the perceptions of students about SDG localization in Zimbabwean universities. The study uses a mixed methods research design. The results reveal that students perceive the SDGs as significant in university curricula.
Lazarus Chapungu, Godwell Nhamo
doaj   +1 more source

What Influences the Diffusion of Grassroots Innovations for Sustainability? Investigating Community Currency Niches [PDF]

, 2016
Community action for sustainability is a promising site of socio-technical innovation. Here we test the applicability of co-evolutionary niche theories of innovation diffusion (Strategic Niche Management, SNM) to the context of ‘grassroots innovations ...
Collom E., Douthwaite R., Geels F. W., Gill Seyfang, Grin J., Gómez G., Hess D., Noel Longhurst, Raven R., Seyfang G.   +9 more
core   +1 more source

Power in sustainability transitions

This chapter delves into the role of power in sustainability transitions, addressing the limited attention power dynamics have received in the field despite their centrality to lasting societal change. Drawing on theories of power from various disciplines, this chapter introduces two conceptual frameworks to analyse power: (1) “power to, over, and with”
Guilherme Raj, Flor Avelino, Marie Claire Brisbois   +2 more
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source