Results 91 to 100 of about 25,118 (264)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Mapping the diversity & transformative potential of approaches to sustainable just cities

open access: yesUrban Transformations
How can cities be more sustainable and just? This question has guided a process of synthesizing insights from previously funded research and innovation projects that deal with approaches tackling urban sustainability and justice. As part of this process,
Flor Avelino   +10 more
doaj   +1 more source

Understanding science-society interactions (SSI): diverse viewpoints from mountain biosphere reserves

open access: yesJournal of Integrative Environmental Sciences
Addressing global challenges necessitates innovative forms of knowledge production such as various forms of science-society interactions (SSI), increasingly endorsed by international initiatives like the UNESCO Man and the Biosphere (MAB) Programme and ...
Alexander Mitrofanenko   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Women and household responsibilities under COVID-19 lockdowns: many steps backwards in implementing SDG 5 in South Africa

open access: yesFrontiers in Global Women's Health
Debates continue regarding the impacts of COVID-19 on women and girls. Lockdowns increased home-based responsibilities, causing work overloads and trauma.
Godwell Nhamo, Malebajoa Anicia Maoela
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

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