Results 91 to 100 of about 1,746,916 (297)

Citizen science and sustainability transitions

Research Policy, 2019
Citizen Science (CS) projects involve members of the general public as active participants in research. While some advocates hope that CS can increase scientific knowledge production ('productivity view'), others emphasize that it may bridge a perceived gap between science and the broader society ('democratization view').
Sauermann, Henry, Vohland, Katrin, Antoniou, Vyron, Balázs, Bálint, Göbel, Claudia, Karatzas, Kostas, Mooney, Peter, Perelló, Josep, Ponti, Marisa, Samson, Roeland, Winter, Silvia   +10 more
openaire   +5 more sources

What is protective space? Reconsidering niches in transitions to sustainability [PDF]

The transitions literature emphasises the role of niches, defined as a protective space for path-breaking innovations. Surprisingly, the concept of protection has not been systematically interrogated.
Rob P.J.M. Raven, Adrian Smith
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Control or coexist with urban baboons: Exploring residents' views and values in Cape Town

Conservation Science and Practice
Humans and wildlife increasingly share urban space, which elevates the risk of negative interactions. Management efforts conventionally focus on controlling species that are considered problematic, but polarization in affected communities' perceptions ...
Kinga Psiuk, Johan Enqvist
doaj   +1 more source

Introduction to Rescaling Sustainability Transitions

Sustainability transitions are employed as a key conceptual term in science, politics and societal debate. While often employed as an umbrella term for policy programmes aiming for a more environmentally and socially conscious shift of societal conduct ...
Albrecht, Moritz, Halonen, Maija, Kuhmonen, Irene   +2 more
core   +1 more source

The Business Model in Sustainability Transitions: A Conceptualization

, 2021
Business models direct a firm’s activity to move in coherence with the objectives of the business. Current literature suggests business models can act as vital forces to facilitate sustainability transitions and highlights the urgent research call to ...
Bocken, Nancy M. P., Anjula Gurtoo, Jain, Akriti, Hernandez-Chea, Roberto, Roberto Hernández-Chea, Bocken, Nancy M.P., Akriti Jain, Gurtoo, Anjula, Nancy M. P. Bocken   +8 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source