Results 111 to 120 of about 213,310 (312)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Citizen science and sustainability transitions

Research Policy, 2019
Citizen Science (CS) projects involve members of the general public as active participants in research. While some advocates hope that CS can increase scientific knowledge production ('productivity view'), others emphasize that it may bridge a perceived gap between science and the broader society ('democratization view').
Sauermann, Henry, Vohland, Katrin, Antoniou, Vyron, Balázs, Bálint, Göbel, Claudia, Karatzas, Kostas, Mooney, Peter, Perelló, Josep, Ponti, Marisa, Samson, Roeland, Winter, Silvia   +10 more
openaire   +5 more sources

Managing Transitions for Sustainable Development [PDF]

, 2006
textabstractThe challenge of sustainable development presents our society with the need for longterm, structural changes or transitions in sectors such as energy-supply, mobility, agriculture and health-care. Based on a multi-phase and multi-level framework for transitions, we ask whether managing transitions is possible and then outline an operational
Loorbach, Derk, Rotmans, Jan
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Negotiating informality and urban resilience: implications for equity

Ecology and Society
Informality is a distinguishing characteristic of cities in the Global South and is strongly associated with urban inequality. Yet, in pursuing resilience, urban resilience strategies and planning have yet to grapple with the role of informality in ...
Hallie Eakin, Johan Enqvist, Maike Hamann, Nadine Methner, Martha Nthambi Sibanda, Jade L Sullivan, Ernita van Wyk, Gina Ziervogel   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Energy transitions and uncertainty: creating low carbon investment opportunities in the UK electricity sector [PDF]

, 2016
This paper examines how actors in the UK electricity sector are attempting to deliver investment in low carbon generation. Low carbon technologies, because of their relative immaturity, capital intensity and low operational costs, do not readily fit with
Channell J, Committee on Climate Change (CCC), DECC, Department of Energy and Climate Change (DECC), EY, Gross R, Helm D, Hoogma R, Hughes T, Infrastructure UK, Keay M, Kern F, Knight FH, Mitchell C, Nelson D, O’Malley P, PricewaterhouseCoopers (PWC), Rhodes C, Ronan Bolton, Stephen Hall, Timothy J Foxon, Waissbein O, Webb J, Williamson O, Winskel M, Winskel M   +25 more
core   +2 more sources

Responsible intellectual property strategy for sustainability transition - An exploratory study

, 2023
Pratheeba Vimalnath, Frank Tietze, Elisabeth Eppinger, Akriti Jain, Anjula Gurtoo, Maximilian Elsen   +5 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Welcome home! Introducing SocSES: a society for inclusive and impactful social-ecological research

Ecology and Society
Underpinned by systemic thinking, social-ecological systems (SES) research has emerged as a critical field for addressing the challenges of the Anthropocene, marked by a cross-scale focus, inter- and transdisciplinary approaches, and a strong emphasis on
Alta de Vos, Allyson Quinlan, Reinette Biggs, Elena M Bennett, Berta Martín-López, Albert V Norström, Garry D Peterson, Michael Schoon, Craig R. Allen, Erik Andersson, Julia Baird, Patricia Balvanera, Marta Berbés-Blázquez, Fikret Berkes, Rafael Calderon-Contreras, Stephen R Carpenter, Antonio J. Castro, Graeme S. Cumming, Marianne Falardeau, W. Liebrecht Fick, Carl Folke, Elson Ian Nyl E Galang, Stefan Gelcich, Line J Gordon, Nancy B Grimm, Jacqueline Hamilton, Jennifer Hodbod, Chinwe Ifejika Speranza, Larissa Koch, Aleksandra Kosanic, Rafael Lembi, Bruno Locatelli, Katja Malmborg, Amanda Manyani, Morgan Mathisonslee, Anahi Ocampo-Melgar, Kinga Psiuk, Cibele Queiroz, Maraja Riechers, Lisen Schultz, Odirilwe Selomane, Kate Sherren, Marja Spierenburg, Micaela Trimble, Francis Turkelboom, Caroline Wallington   +45 more
doaj   +1 more source