Results 151 to 160 of about 1,746,916 (297)

What opportunities could the COVID-19 outbreak offer for sustainability transitions research on electricity and mobility? [PDF]

Energy Res Soc Sci, 2020
Kanda W, Kivimaa P.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Global gridded population datasets systematically underrepresent rural population

Nature Communications
Numerous initiatives towards sustainable development rely on global gridded population data. Such data have been calibrated primarily for urban environments, but their accuracy in the rural domain remains largely unexplored.
Josias Láng-Ritter, Marko Keskinen, Henrikki Tenkanen   +2 more
doaj   +1 more source

Sustainability transitions in the context of pandemic: an introduction to the focused issue on social innovation and systemic impact. [PDF]

Agric Human Values, 2020
Desa G, Jia X.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Turning points for sustainability transitions: Institutional destabilization, public finance and the techno-economic dynamics of decarbonization in South Africa. [PDF]

Energy Res Soc Sci, 2020
Walwyn DR.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Contextualizing the Covid-19 pandemic for a carbon-constrained world: Insights for sustainability transitions, energy justice, and research methodology. [PDF]

Energy Res Soc Sci, 2020
Sovacool BK, Furszyfer Del Rio D, Griffiths S.   +2 more
europepmc   +1 more source

Mapping mental models in sustainability transitions [PDF]

Sustainability transitions inherently involve system change, which needs to be initiated and accepted by a wide variety of actors. How actors perceive the system or transition of interest can shape key decisions in a transition process.
Negro, Simona, van den Broek, Karlijn, Hekkert, Marko   +2 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source