Results 161 to 170 of about 213,310 (312)
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Making Sustainability Transitions Appealing: The Need for Alternative Narratives in France
Blue PapersSustainability transitions offer opportunities to rethink and improve society, such as by improving well-being, reducing inequalities and reconnecting with nature.
Maëlle Salzinger
doaj +1 more source
Combining nested markets and the multilevel perspective to understand the agroecological transition of the food system [PDF]
, 2018 A twofold framework based on nested markets and the multi-level perspective on sustainable transitions is presented. We argue that there are promising intersections between these interrelated concepts, which are useful to understand the emerging dynamics
Cerdan, Claire +3 more
core
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Global gridded population datasets systematically underrepresent rural population
Nature CommunicationsNumerous initiatives towards sustainable development rely on global gridded population data. Such data have been calibrated primarily for urban environments, but their accuracy in the rural domain remains largely unexplored.
Josias Láng-Ritter +2 more
doaj +1 more source
Research and practice of sustainability transitions in the Netherlands [PDF]
, 2009 This paper reports on the research outcomes and practical experiences with transitions and transition management in the Netherlands. Transitions are phenomena that receive increasing interest from researchers, policy-makers and the business community as ...
Loorbach, D.A. (Derk), Rotmans, J. (Jan)
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source