Results 141 to 150 of about 213,310 (312)
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Theoretical multiplicity for the governance of transitions. The energy producing greenhouse case [PDF]
Transition management, as a theory of directing structural societal changes towards sustainable system innovations, has become a major topic in scientific research over the last years.
Dewulf, A., Termeer, C.J.A.M.
core
Civil society roles in transition: towards sustainable food? [PDF]
, 2014 Civil society organisations (CSOs) are often conspicuously absent in policy discussions and strategic planning about food security and the environmental sustainability of food systems.
Durrant, Rachael
core +1 more source
Achieving Sustainable Development Goals in Nigeria’s power sector: assessment of transition pathways [PDF]
, 2019 María Yetano Roche +5 more
openalex +1 more source
ECOFLOTA: Business intelligence system for the transition towards sustainable mobility fleets
, 2021 Sergio Güerri
openalex +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Fostering energy efficiency dynamics through ex-ante strategic niche management: the UK perspective [PDF]
, 2013 The United Kingdom building sector has been challenged to retrofit a huge stock of existing buildings in order to increase its adaptive capacity for climate change impacts.
Goulding, Jack Steven +2 more
core
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source