Results 41 to 50 of about 217,063 (254)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Transitions to Sustainability [PDF]

, 2015
International ...
Mancebo, Francois, Sachs, Ignacy
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Open IP strategies for enabling sustainability transitions [PDF]

, 2016
As global societies are evolving to knowledge economies, intellectual property (IP) is becoming increasingly important. Contemporaneously, firms are opening up their innovation processes in contrast to the internally focused closed innovation paradigm ...
,, Eppinger, E, Sternkopf, J, Tietze, F, Vimalnath, P   +4 more
core   +2 more sources

High-Tech Urban Agriculture in Amsterdam : An Actor Network Analysis [PDF]

, 2020
The agriculture and horticulture sector in the Netherlands is one of the most productive in the world. Although the sector is one of the most advanced and intense agricultural production systems worldwide, it faces challenges, such as climate change and ...
Carsjens, Gerrit J., Farhangi, Mohsen H., Turvani, Margherita E., van der Valk, Arnold   +3 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Nudging sustainability transitions in Central Mozambique [PDF]

, 2019
An Agricultural Innovation Platform (AIP) facilitates and accelerates transition of farmers from subsistence farming to socially inclusive, environmentally sound and market-oriented farming. AIPs adapt interventions around interlinked levers in the
Falk, T., Gungulo, A., Homann-Kee Tui, Sabine, Quembo, C., Sixpence, C.   +4 more
core  

Framing the collaborative economy - Voices of contestation [PDF]

, 2017
Within the context of multiple crises and change, a range of practices discussed under the umbrella term of collaborative (or sharing) economy have been gaining considerable attention.
Gruszka, Katarzyna
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Energy transitions and uncertainty: creating low carbon investment opportunities in the UK electricity sector [PDF]

, 2016
This paper examines how actors in the UK electricity sector are attempting to deliver investment in low carbon generation. Low carbon technologies, because of their relative immaturity, capital intensity and low operational costs, do not readily fit with
Channell J, Committee on Climate Change (CCC), DECC, Department of Energy and Climate Change (DECC), EY, Gross R, Helm D, Hoogma R, Hughes T, Infrastructure UK, Keay M, Kern F, Knight FH, Mitchell C, Nelson D, O’Malley P, PricewaterhouseCoopers (PWC), Rhodes C, Ronan Bolton, Stephen Hall, Timothy J Foxon, Waissbein O, Webb J, Williamson O, Winskel M, Winskel M   +25 more
core   +2 more sources