Results 61 to 70 of about 217,063 (254)

Comparing nuclear power trajectories in Germany and the UK: from ‘regimes' to ‘democracies’ in sociotechnical transitions and Discontinuities [PDF]

, 2015
This paper focuses on arguably the single most striking contrast in contemporary major energy politics in Europe (and even the developed world as a whole): the starkly differing civil nuclear policies of Germany and the UK. Germany is seeking entirely to
A Aliseda, A Bergek, A Blowers, A Corner, A Glaser, A Gramsci, A Held, A Hommels, A Lijphart, A Lijphart, A Lovins, A Massey, A Pegels, A Piening, A Schutz, A Sen, A Sen, A Smith, A Smith, A Smith, A Smith, A Smith, A Smith, A Stirling, A Stirling, A Stirling, A Verbruggen, Andy Stirling, B B F Wittneben, B Doherty, B Flyvbjerg, B Griffin, B Hancke, B K Sovacool, B K Sovacool, B K Sovacool, B K Sovacool, B Latour, B Turnheim, B Wynne, B Wynne, Bbc News, Blowers, Bvg Associates, C A Miller, C Barnett, C C R Penna, C Cottarelli, C Crouch, C Klessmann, C Kuzemko, C Li, C M Hendriks, C M Hendriks, C Mitchell, D Campbell, D Clements, D Elliott, D Haraway, D Harvey, D J Hess, D J Hess, D Jahn, D Jahn, D Johnson, D King, D P Mccormack, D Rucht, D Toke, D Toke, Decc, Decc, Decc, E F Borgatta, E Kahn, E Laclau, E Laclau, E Shove, E Shove, E Swyngedouw, Edf Energy, Enf Solar, Ewea, F Berkhout, F Berkhout, F Geels, F Geels, F Kern, F Kern, F Kern, F Kern, F Kern, F L�v�que, F Malerba, F W Geels, F W Geels, F W Geels, F W Geels, F W Geels, F W Geels, Ffree, G C Unruh, G Harris, G Hecht, G L Munck, G Mackerron, G Munk, G Resch, G Resch, G Ritzer, G Smith, G Strohmeier, G Verbong, G Verbong, G Winter, German Bundestag, Globalscan, Gns, H Chalmers, H E Normann, H Marcuse, H P Kitschelt, Hm Government, Hm Government, I Bailey, I Lovinfosse, I Welsh, Iaea, Ipsos Mori, Irena, J A Camilleri, J Allouche, J Byrne, J C Scott, J Deign, J Dewey, J Downing, J Grin, J Huenteler, J Jewell, J Lipp, J Markard, J Markard, J Meadowcroft, J Mecklin, J Nill, J Pligt, J R Josephson, J Rotmans, J S Dryzek, J Schot, J Wilson, K Barnham, K Bergeron, K Bickerstaff, K Bruninx, K Hartley, K Kleiner, K Pavitt, K Rogge, K Smith Stegen, L Arnold, L Baker, L Coenen, L Magnani, L Veneklasen, L Winner, L�v�que, M Berth�lemy, M Blyth, M Bookchin, M B�hlmann, M B�hlmann, M J Witkamp, M Leach, M Lenzen, M Lockwood, M Lockwood, M Lockwood, M Lynas, M M Smink, M Mazzucato, M Purdue, M R Fhg-Isi, M Schneider, M V Ramana, M Weber, Mod, N Carter, N E Hultman, N Guild, N Luhmann, N Marres, Nukem, O Renn, P Bourdieu, P Bradford, P Delrio, P Hall, P Hall, P Johnstone, P Linares, P Pierson, P Stegmaier, Philip Johnstone, R Cowan, R Cowell, R E H Sims, R Eckstein, R Edwards, R Kemp, R Kemp, R Milne, R Nelson, R Norris, R Raven, R Simon, R Yin, Renewableuk, Rip, Royce Rolls, S ?i?ek, S ?i?ek, S Ansari, S Jacobsson, S Jasanoff, S Jasanoff, S Jhagroe, S Lukes, S Squassoni, S Strunz, S Thomas, S Thomas, S Thomas, Schrader-Frechette, T Bijker, T Hughes, T O&apos, U J�rgensen, U K Germany, Urenco, V Lauber, V M Fthenakis, W Arthur, W L�tkenhorst, W Nuttall, W Patterson, W Patterson, W Rudig, W Walker, Y Peng, Y.-H Sun   +251 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Product Service System Innovation in the Smart City [PDF]

, 2018
Product service systems (PSS) may usefully form part of the mix of innovations necessary to move society toward more sustainable futures. However, despite such potential, PSS implementation is highly uneven and limited.
Aoun C, Behrendt S, Brezet JC, Dosi G, Gehl J, Gottberg A, Guy S, Joss S, Massey D, Meijkamp R, Robson C, Skea J, Tukker A, Weizsacker E, Zaring O   +14 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Unfolding sustainability transitions in food systems: Insights from UK and French trajectories. [PDF]

Proc Natl Acad Sci U S A, 2023
Lamine C, Marsden T.
europepmc   +1 more source

How to facilitate the implementation and diffusion of sustainable Product-Service Systems? Looking for synergies between strategic design and innovation sciences [PDF]

, 2010
Copyright @ 2010 Greenleaf PublishingEco-efficient Product-Service System (PSS) innovations represent a promising approach to sustainability. However the application of this concept is still very limited because eco-efficient PSS are intrinsically ...
Ceschin, F
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

How policies and actor strategies affect electric vehicle diffusion and wider sustainability transitions. [PDF]

Proc Natl Acad Sci U S A, 2023
Ryghaug M, Skjølsvold TM.
europepmc   +1 more source

The value of theoretical multiplicity for steering transitions towards sustainability [PDF]

, 2009
Transition management, as a theory of directing structural societal changes towards sustainable system innovations, has become a major topic in scientific research over the last years.
Breeman, G.E., Dewulf, A., Pot, W.D., Termeer, C.J.A.M., Werkman, R.A.   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source