Results 81 to 90 of about 220,364 (303)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Energy transitions and uncertainty: creating low carbon investment opportunities in the UK electricity sector [PDF]

, 2016
This paper examines how actors in the UK electricity sector are attempting to deliver investment in low carbon generation. Low carbon technologies, because of their relative immaturity, capital intensity and low operational costs, do not readily fit with
Channell J, Committee on Climate Change (CCC), DECC, Department of Energy and Climate Change (DECC), EY, Gross R, Helm D, Hoogma R, Hughes T, Infrastructure UK, Keay M, Kern F, Knight FH, Mitchell C, Nelson D, O’Malley P, PricewaterhouseCoopers (PWC), Rhodes C, Ronan Bolton, Stephen Hall, Timothy J Foxon, Waissbein O, Webb J, Williamson O, Winskel M, Winskel M   +25 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Nudging sustainability transitions in Central Mozambique [PDF]

, 2019
An Agricultural Innovation Platform (AIP) facilitates and accelerates transition of farmers from subsistence farming to socially inclusive, environmentally sound and market-oriented farming. AIPs adapt interventions around interlinked levers in the
Falk, T., Gungulo, A., Homann-Kee Tui, Sabine, Quembo, C., Sixpence, C.   +4 more
core  

Open IP strategies for enabling sustainability transitions [PDF]

, 2016
As global societies are evolving to knowledge economies, intellectual property (IP) is becoming increasingly important. Contemporaneously, firms are opening up their innovation processes in contrast to the internally focused closed innovation paradigm ...
,, Eppinger, E, Sternkopf, J, Tietze, F, Vimalnath, P   +4 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Control or coexist with urban baboons: Exploring residents' views and values in Cape Town

Conservation Science and Practice
Humans and wildlife increasingly share urban space, which elevates the risk of negative interactions. Management efforts conventionally focus on controlling species that are considered problematic, but polarization in affected communities' perceptions ...
Kinga Psiuk, Johan Enqvist
doaj   +1 more source

Cabbage, Curation and the Convivial

Journal of Awareness-Based Systems Change
This article explores an artist-led research residency centred on a participatory cabbage fermentation ritual as a lens for systems change. Drawing on arts-based and postqualitative methodologies, the work engages with food, ritual, and somatic knowing ...
Miche Fabre Lewin, Flora Gathorne-Hardy, Rika Preiser   +2 more
doaj   +1 more source

Social movements in sustainability transitions : identity, social learning & power in the Spanish & Turkish water domains / [PDF]

, 2010
Descripció del recurs: el 02 de novembre de 2010Dominant economic growth and nation-state building practices are often based on detaching individuals from other individuals and communities from their natural environment in which their livelihoods used to
Ilhan, Akgün, Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals   +1 more
core   +1 more source

Product Service System Innovation in the Smart City [PDF]

, 2018
Product service systems (PSS) may usefully form part of the mix of innovations necessary to move society toward more sustainable futures. However, despite such potential, PSS implementation is highly uneven and limited.
Aoun C, Behrendt S, Brezet JC, Dosi G, Gehl J, Gottberg A, Guy S, Joss S, Massey D, Meijkamp R, Robson C, Skea J, Tukker A, Weizsacker E, Zaring O   +14 more
core   +1 more source