Results 91 to 100 of about 4,669,831 (317)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
, 2011 We need to radically re-think typography for text-rich business documents & publications (not referring to books). Most designers assume people have time to read. In reality the following occurs: Observations: 1) We browse/forage (71%) then read (11%)
Ashley, Martin
core
Sustainable Tourism, Towards Sustainable Development [PDF]
, 2018 Following the previous two chapters on sectorial applications of sustainable project management, the tourism sector has been identified as one of the most influential contributors to the economic growth of many developing countries. The growing influence of the tourism sector as an economic powerhouse and its potential as a tool for development are ...
Ljubomir Janjusevic, Mohamed Salama
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Editorial: Environmental isotopes for water resource management
Frontiers in Water, 2023 Prasanna Mohan Viswanathan +3 more
doaj +1 more source
Energy embodied in household cookery: the missing part of a sustainable food system? Part 1: A method to survey and calculate representative recipes [PDF]
, 2017 This paper firstly reviews the current state of knowledge on sustainable cookery and the environmental impacts of the food consumption phase. It then uses the example of a dish of roast beef and Yorkshire pudding to explore energy use in food production ...
Bajželj +31 more
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Sustainability of “Sustainable Consumption” [PDF]
Journal of Macromarketing, 2002 This article examines the limitations of the concept of sustainable consumption in terms of the inadequate attention given to the social, cultural, and historical contextualization of consumption. The author argues that macromarketing should adopt modes of inquiry that fully engage with this contextualization.
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Editorial: Agriculture and food supply challenges in a changing climate
Frontiers in Climate, 2023 Ka Ming Fung +4 more
doaj +1 more source