Results 91 to 100 of about 328,877 (308)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

SUSTAINABLE TOURISM – A DYNAMICS METHOD FOR DESTINATION PLANNING Community approach: A case from south of Albania [PDF]

open access: yes
The main aim of this paper is directed in exploring alternative and sustainable tourism not only as one of the main sector of Albanian Economy, but as a planning tool from the community approach view. All the master plans, dynamics processes that involve
Dorina Kripa   +2 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Biosurfactant production by fungi as a sustainable alternative

open access: yesArquivos do Instituto Biológico, 2018
: A wide variety of bacteria is far more exploited than fungi as biosurfactants (BS) or bioemulsifiers (BE), using renewable sources. BS are considered to be environmentally safe and offer advantages over synthetic surfactants.
Artemisia Carla Santos da Silva   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Building a Sustainable Business: A Guide to Developing a Business Plan for Farms and Rural Businesses.

open access: yes, 2003
Third printing, 2010. 289p. Co-published by the Sustainable Agriculture Research and Education (SARE) program."We hope this Business Planning Guide will assist today’s alternative and traditional business owners alike with the creation of a holistic ...
Minnesota Institute for Sustainable Agriculture
core  

Determinants of Receptivity Towards Entomophagy among Young Adults

open access: yesMercados y Negocios
This research focuses on understanding the factors influencing the acceptance of entomophagy in Morelia, Michoacán. The study involves a survey aimed at two distinct groups of young adults aged 18 to 29 (control and experimental), a demographic known for
Carlos Francisco Ortiz Paniagua   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

The Architecture of Sustainable University Foodscape. Design Strategies and Practices for Reshaping the Food-City Nexus

open access: yes
In recent decades food projects, practices and policies enacted by universities have multiplied, crossing the spheres of teaching, research and the third mission. However, the perspective of urban and architectural design still seems to be underestimated
Sara Basso, Valentina Rodani
core   +1 more source

Co-housing as a socio-ecologically sustainable alternative?

open access: yes, 2019
Co-housing has been framed as an answer to demands on reducing the ecological impact from the built environment and on modern ecological friendly lifestyles, with a growing group of socially and environmentally conscious residents pursuing alternative ...
Pernilla Hagbert, Hagbert, Pernilla,
core   +1 more source

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