Results 51 to 60 of about 1,478,432 (305)

Economic alternatives and childhood poverty [PDF]

open access: yes, 2008
Current national and international economic policies are exerting ever more direct pressures on children's lives and futures. This paper reviews key concerns and contradictions in neoliberal economic policies' effects on childhood.
Alderson, Priscilla
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Harnessing fuel cell and PVT for cogeneration in buildings: A comparative analysis in different climates

open access: yesCase Studies in Thermal Engineering
This study compares the performance of two hybrid residential cogeneration systems—a photovoltaic–thermal (PVT) system and a solid oxide fuel cell (SOFC) system.
Malik Alamayreh   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Socio-ecological Approach to Measure Progress for Ontario’s Transition to a Green Economy: The Use of the Happy Planet Index [PDF]

open access: yes, 2019
Government tends to look at economic growth and GDP as the primary measure of wellbeing in society. However, GDP does not consider many environmental impacts which have critical short and long-term economic effects.
Robinson, Jason
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Sustainable control of Anopheles mosquito population [PDF]

open access: yes, 2014
Despite the widespread use of insecticides, community engagement programmes and preventive measures mosquito borne diseases are growing and new tools to prevent the spread of disease are urgently needed. An alternative control measure for the eradication
Birch, Philip   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Application of Artificial Intelligence in Transportation Demand Management: Development and Implementation of E-sutra [PDF]

open access: yes, 2013
Allowing traffic to grow to a level at which there is extensive and regular congestion is economically inefficient. Although the construction of additional roads can alleviate some of the effects of congestion, the benefits may be counterbalanced unless ...
Ircham, I. (Ircham)   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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