Results 81 to 90 of about 468,681 (298)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

INTEGRATION OF SERVICE LIFE IN THE PROCESS OF MANAGEMENT AND DESIGN OF BUILDINGS [PDF]

This article approaches the regulatory framework on the service life of constructed assets and its integration into the management and design process of sustainable buildings.
Silverio HERNÁNDEZ-MORENO
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Software engineering challenges: Achieving zero carbon buildings by 2019 [PDF]

, 2010
The planet Earth is warming up. There is an urgent need to reduce greenhouse gas emissions. Buildings account for almost 50% of UK carbon dioxide emissions.
Hetherington, Robina, Laney, Robin C., Peake, Stephen   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Assessment of Natural Ventilation Potential for Residential Buildings across Different Climate Zones in Australia

Atmosphere, 2017
In this study, the natural ventilation potential of residential buildings was numerically investigated based on a typical single-story house in the three most populous climate zones in Australia.
Zijing Tan, Xiang Deng
doaj   +1 more source

High quality indoor environments for sustainable office buildings [PDF]

, 2008
The quality of office indoor environments is considered to consist of those factors that impact occupants according to their health and well-being and (by consequence) their productivity.
Brown, Stephen K
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Modulation of the Intensity of the Spectral Components of Polychromatic Light within Certain Regions in Space by Passive Methods by Strategically Using Material Optical Properties and Texture

Technologies, 2018
Recent research indicates that not only blue and green monochromatic light stimulates our circadian system, but polychromatic light as well. Recent work also suggests that the human circadian system also changes its spectral sensitivity with different ...
Adriana Lira-Oliver
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Obama Administration FY 2015 Budget Proposal: Sustainable Energy, Buildings, Transportation and Climate [PDF]

, 2014
President Obama released his $3.9 trillion fiscal year (FY) 2015 budget proposal for the federal government on March 4, 2014. The budget reflects the administration's "all of the above" energy strategy as well as its reinvigorated focus on addressing ...

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