Results 81 to 90 of about 482,645 (303)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Sustainable farming with native rocks: the transition without revolution. [PDF]
, 2006 The development process which humanity passed through favored a series of conquests, reflected in the better quality of life and longevity, however, it also provoked upsets and severe transformation in the environment and in the human food security. Such
ALTIERI MA +15 more
core +4 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Green Processing and Synthesis, 2012 Sustainable chemistry is the attempt to design chemical products and processes that reduce or eliminate the use and generation of hazardous substances, minimize waste and energy consumption, favor renewable resources and integrate aspects of recycling ...
Hempel Maximilian
doaj +1 more source
Metal-Free Reduction of Phosphine Oxides Using Polymethylhydrosiloxane
Inorganics, 2016 A simple protocol is presented here for the use of inexpensive polymethylhydrosiloxane (PMHS), a waste product of the silicon industry, as stoichiometric reducing agent for phosphine oxides to phosphines, a highly desirable reaction to recover P-based ...
Emmanuel Nicolas +6 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Química verde: a evolução de um conceito
Química Nova, 2014 The topic "Green Chemistry" has gained great importance over recent years, being quoted in an increasing number of publications. This fact shows how concern over developing "greener" processes has played a prominent role in the scientific community.
Eduardo F. Sousa-Aguiar +4 more
doaj +1 more source
A strategic niche management approach for shaping bio-based economy in Europe [PDF]
, 2018 The goal of this paper is to investigate the transition towards a bio-based economy as part of a broader sustainable transition in Europe. To analyse the challenges and opportunities associated with the bio-based economy, we applied the Strategic Niche ...
Tani, Almona
core +1 more source