Results 71 to 80 of about 1,998,315 (284)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Design for Social and Environmental Enterprise [PDF]

open access: yes, 2009
SEED Foundation undertakes action research to develop new, innovative ways for design to most effectively contribute towards sustainable development. The research that follows is not the result of academic investigations but rather, a culmination of 20 ...
Bowden, Flora, Brass, Clare
core  

Climate Responsive Design Simulation and Modelling for Industrial Heritage [PDF]

open access: yes, 2018
The control of solar radiation is a basic dimension of modern design in all different types of constructions. Many architects have recently observed that different phases of sustainable design require a set of calculations and simulations that are ...
Castilla Roldán, Manuel-Viggo
core   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

An Evaluation of Existing On-Line Learning & Teaching Resources for the Socio-Economic Aspects of Sustainable Design, New Perspectives in Design Education [PDF]

open access: yes, 2008
This paper fits into the topic of eco-design education and explores questions related to the modern student’s perspective on design education and how we should consider the curricula from a future perspective.
Humphries-Smith, Tania
core  

Sustainable Transportation System Design [PDF]

open access: yes, 2019
As reducing the carbon footprint became one of the topmost concerns of the firms, Company X Turkey has a goal of transforming all of its operations in environmentally sustainable manner. Therefore, they specified their main goal as reducing yearly carbon emission levels of the company by five percent calculated in key performance indicator.
Utku, İ. Y.   +6 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Development of a Disposable Single-Nozzle Printhead for 3D Bioprinting of Continuous Multi-Material Constructs

open access: yesMicromachines, 2020
Fabricating multi-cell constructs in complex geometries is essential in the field of tissue engineering, and three-dimensional (3D) bioprinting is widely used for this purpose. To enhance the biological and mechanical integrity of the printed constructs,
Tiffany Cameron   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sustainable Value Proposition Design in a Product-Service System [PDF]

open access: yes, 2012
Many companies have started to add services to their tangible products in order to defend themselves from increased competition from low-cost economies.
Kristofer Nygren, Niclas Österlind
core  

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