Results 101 to 110 of about 16,511,013 (283)

Effect of discontinuous fair-share emissions allocations immediately based on equity

Nature Communications
National emissions targets are collectively insufficient to align with the Paris Agreement. The fair-share literature assesses whether these targets are fair and ambitious in comparison to emissions trajectories based on equity principles. Such emissions
Yann Robiou du Pont, Mark Dekker, Detlef van Vuuren, Michiel Schaeffer   +3 more
doaj   +1 more source

Energy security assessment in rural communities in Brazil: A contribution to public policies

Energy Nexus
Energy security refers to the continuous and reliable access to energy sources at an affordable cost. In rural areas, particularly in Brazil's semi-arid regions, this security is essential for the survival and development of communities.
Wesly Jean, Marcel Bursztyn, Elton S. Oliveira, Júlia Lopes, Guadalupe Sátiro, Saulo Rodrigues Filho, Diego Lindoso, Juliana Dalboni Rocha, Nelson Bernal, Daniela Nogueira   +9 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Household smoke exposure risk and acute respiratory infection among children under five years in sub-Saharan Africa: evidence from the demographic and health surveys

BMC Public Health
Background Exposure to smoke from unclean fuels increases children’s risk of acute respiratory infection (ARI). Although studies have extensively examined the association between the type of cooking fuel used and ARI in sub-Saharan Africa (SSA), few have
Michael Larbi Odame, Rexford Kweku Asiama, Margaret Appiah, Grace Frempong Afrifa-Anane, Frank Kyei-Arthur   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Sustainable development : third annual assessment of progress by the Scottish Government [PDF]

, 2012
Contents: Sustainable development : third annual assessment of progress by the Scottish Government -- Annexe 1: Scottish Government indicator and target data -- Annexe 2: Scottish Government indicator and target analysis -- Annexe 3: Delivery on ...
Sustainable Development Commission Scotland
core   +2 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source