Results 91 to 100 of about 16,511,013 (283)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Consultation on developing the annual health check in 2006/2007 : response from the Sustainable Development Commission [PDF]
, 2012 Sustainable Development Commission response to the Healthcare Commission’s proposals for assessing the performance of healthcare organisations in England as set out in 'Developing the annual health check in 2006/2007'.Publisher ...
Sustainable Development Commission
core +2 more sources
International Journal of Chemical EngineeringPolyethylene (PE) accounts for approximately 40% of total global plastic production, yet PE waste remains an underutilized feedstock. Meanwhile, activated carbon (AC) derived primarily from coconut shells (CS), the most popular source, is usually ...
Junaid Saleem +3 more
doaj +1 more source
Journal of Agriculture and Rural Development in the Tropics and SubtropicsThis study examines gender disparities in access to agricultural land and participation, using a sample of 200 cashew farmers in the Kintampo South District of Ghana and descriptive statistical analysis.
Daniella Delali Sedegah
doaj +1 more source
International Journal of Disaster Risk Science, 2018 South Asia is vulnerable to a variety of hydrometeorological hazards, which are often cross-boundary in nature. Climate change is expected to influence many of these hazards.
Rajesh K. Mall +5 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The next steps : an independent review of sustainable development in the English regions : executive summary [PDF]
, 2012 Executive summary of 'The next steps : an independent review of sustainable development in the English regions'. In its Annual Review for 2005-2006, the Sustainable Development Commission put forward an alternative vision for the future, a path to ...
Sustainable Development Commission
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source