Results 81 to 90 of about 16,511,013 (283)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Riverine communities in the Central Amazon are largely subject to erosion and sedimentation risk
Communications Earth & EnvironmentSedimentary processes cause large changes in riverscapes and alter river banks and margins, leading to major hazards for riverine communities. However, regional mapping of the resulting risk remains scarce, especially in remote Amazon regions.
André Zumak +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Sustainable development in government 2008 : challenges for government [PDF]
, 2012 Our seventh annual SDiG assessment found good overall progress by the UK Government, especially on targets for water, waste and travel, though reductions in carbon emissions from offices were still not on track.Publisher ...
Sustainable Development Commission
core +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A sustainable new deal : a stimulus package for economic, social and ecological recovery [PDF]
, 2012 Sustainable Development Commission's advice to Government on how to revive the UK's economy through a green recovery package.Publisher ...
Sustainable Development Commission
core +2 more sources
International Journal of Recycling of Organic Waste in Agriculture, 2018 Purpose In the present study, effect of earthworm-processed MSW was seen on biochemical, physiological, and yield responses of Abelmoschus esculentus L. Methods Plants were grown on different amendment ratios of municipal solid waste vermicompost (MSWVC).
Vaibhav Srivastava +4 more
doaj +1 more source