Multiple sclerosis clinical decision support system based on projection to reference datasets
Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch+13 more
wiley +1 more source
Securing good health for the whole population (Wanless Review) : submission from the SDC [PDF]
The Sustainable Development Commission fully supports the terms of reference contained in the document 'Securing good health for the whole population : final report'.
Sustainable Development Commission
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FoxO1 signaling in B cell malignancies and its therapeutic targeting
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac+3 more
wiley +1 more source
Effects of pregnancy on neuromyelitis optica spectrum disorder and predictors of related attacks
Abstract Objective Our study aimed to investigate the influence of pregnancy on the course of neuromyelitis optica spectrum disorders (NMOSD) and to explore the independent predictors of pregnancy‐related attacks. Methods We performed a retrospective study of patients with NMOSD based on the Wingerchuk 2006 or the revised Wingerchuk 2015 criteria ...
Qin Du+7 more
wiley +1 more source
Post-(sustainable) development?
AbstractThe past 15 years have witnessed the rise of post‐development theory as a means of understanding the development discourse since the 1940s. Post‐development argues that intentional development (as distinct from immanent development – what people are doing anyway) is a construct of Western hegemony.
openaire +9 more sources
Comments back from the Sustainable Communities Summit Workshop : creating communities with low environmental impact [PDF]
Based on 'Report back from Sustainable Communities Summit Workshop : creating communities with a low environmental impact'.Publisher ...
Sustainable Development Commission
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Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi+3 more
wiley +1 more source
Does long‐term phenytoin have a place in Dravet syndrome?
Abstract Anti‐seizure medications that block sodium channels are generally considered contraindicated in Dravet syndrome. There is, however, considerable debate about the sodium‐channel blocker phenytoin, which is often used for status epilepticus, a frequent feature of Dravet syndrome.
George A. Zographos+2 more
wiley +1 more source
Putting Sustainability into Sustainable Human Development [PDF]
Abating the threat climate change poses to the lives of future people clearly challenges our development models. The 2011 Human Development Report rightly focuses on the integral links between sustainability and equity. However, the human development and capabilities approach emphasizes the expansion of people's capabilities simpliciter, which is ...
Peeters, Wouter+2 more
openaire +4 more sources
UK Citizen’s Council for the future : creating new spaces for citizens’ voices and long-term thinking in politics [PDF]
This paper sets out the rationale and requirement for a citizens' council, a new space for UK citizens to engage with and inform long-term political thinking.Publisher ...
Sustainable Development Commission
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