Results 41 to 50 of about 1,229,835 (284)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Land, 2023 Land use and land cover (LULC) changes are of vital significance in fields such as environmental impact assessment and natural disaster monitoring. This study, through an analysis of 1432 papers over the past decade employing quantitative, qualitative ...
Caixia Rong, Wenxue Fu
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Global annual wetland dataset at 30 m with a fine classification system from 2000 to 2022
Scientific DataWetlands play a key role in maintaining ecological balance and climate regulation. However, due to the complex and variable spectral characteristics of wetlands, there are no publicly available global 30-meter time-series wetland dynamic datasets at ...
Xiao Zhang +5 more
doaj +1 more source
International Journal of Digital Earth, 2023 Spaceborne photon-counting LiDAR is significantly affected by noise, and existing denoising algorithms cannot be universally adapted to different surface types and topographies under all observation conditions.
Jieying Lao +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
The Sustainable Development Goals: One-Health in the World’s Development Agenda [PDF]
, 2015 The Sustainable Development Goals (SDGs), adopted by the UN General Assembly in September 2015, embody a One-Health strategy—healthy people living on a habitable planet. Extending beyond the social development emphasis of the Millennium Development Goals
Friedman, Eric A., Gostin, Lawrence O.
core +1 more source
Open Education and the Sustainable Development Goals: Making Change Happen [PDF]
, 2017 Education for All has been a concept at the heart of international development since 1990 and has found its latest instantiation within the Sustainable Development Goals (SDGs) as SDG 4, ‘Ensure inclusive and equitable quality education and promote ...
Lane, Andy
core +3 more sources
Checkpoint blockade and the stem‐like T cell trade‐off
Molecular Oncology, EarlyView.Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley +1 more source
International Journal of Digital EarthThe Multispectral Imager (MII) onboard the newly launched SDGSAT-1 holds significant promise for monitoring and understanding variations in water quality within nearshore water systems, with an impressive spatial resolution of 10 m, seven spectral bands ...
Shenglei Wang +8 more
doaj +1 more source