Results 61 to 70 of about 17,581,732 (279)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Land, 2023 Land use and land cover (LULC) changes are of vital significance in fields such as environmental impact assessment and natural disaster monitoring. This study, through an analysis of 1432 papers over the past decade employing quantitative, qualitative ...
Caixia Rong, Wenxue Fu
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Blue Papers, 2023 The Sustainable Development Goals Working Group (SDGWG) of the International Council on Monuments and Sites (ICOMOS) advocates for heritage by publishing reports, attending conferences and engaging in networking.
Gabriel Caballero +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
International Journal of Digital EarthThe Multispectral Imager (MII) onboard the newly launched SDGSAT-1 holds significant promise for monitoring and understanding variations in water quality within nearshore water systems, with an impressive spatial resolution of 10 m, seven spectral bands ...
Shenglei Wang +8 more
doaj +1 more source
International Journal of Digital Earth, 2023 Spaceborne photon-counting LiDAR is significantly affected by noise, and existing denoising algorithms cannot be universally adapted to different surface types and topographies under all observation conditions.
Jieying Lao +6 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Spatiotemporal Analysis of Photovoltaic Potential in Ordos City Based on an Improved CRITIC Method
LandIn view of the contradiction between the still-high energy consumption in Ordos and the increasingly urgent carbon-neutral goal, the adjustment of energy structures has begun, and strategic planning of photovoltaic facility construction critically ...
Yifei Guo +4 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source