Results 121 to 130 of about 481,387 (312)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Sustainable communities and sustainable development : a review of the Sustainable Communities Plan
, 2012 This report is based on 'Sustainable communities : building for the future' by the Office of the Deputy Prime Minister (2003).'Sustainable communities : building for the future' was drawn up by the Office of the Deputy Prime Minister in order to tackle ...
Power, Ann
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Sustainable Growth with Environmental Spillovers: A Ramsey-Koopmans Approach [PDF]
In this paper, we apply the canonical approach of Ramsey, Koopmans, and Diamond to the problem of optimal and intertemporally-equitable growth with a non-renewable resource constraint and show that the solution is sustainable.
Lee H. Endress +2 more
core
Redefining Economic Policy and Institutional Reform – Support for Economic Growth [PDF]
Theoretical and Applied Economics, 2010 The paper addresses the effects of economic crisis fromthe perspective of theoretical developments and how they were reflectedin the economy, both nationally and among the actors of the internationalsystem.
Coralia ANGELESCU, Laurenţiu DINU
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A new long-term measure of sustainable growth under uncertainty. [PDF]
PNAS Nexus, 2022 Okabe T, Yoshimura J.
europepmc +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
The Statistical Approach to Understanding the Interdependencies Among Sustainable Development Goals
ECONOMICSThis paper comprehensively analyses the interdependencies among the Sustainable Development Goals (SDGs) through Canonical Correlation Analysis (CCA). By categorizing SDGs into Social Development Goals, Environmental Sustainability Goals, and Economic ...
Liashenko Oksana, Dluhopolskyi Oleksandr
doaj +1 more source
Toward a sustainable growth path in Arab economies: an extension of classical growth model. [PDF]
Financ Innov, 2023 Taha A +4 more
europepmc +1 more source