Results 101 to 110 of about 302,151 (264)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

KNOWLEDGE-INTENSIVE SERVICES AND THEIR EFFECT ON ECONOMIC GROWTH [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015
This paper starts from the idea that the key determinants for economic growth can be: smart growth (promoting knowledge, innovation, education and the digital society), sustainable growth (a more competitive production, with a better use of resources ...
CIOBAN GABRIELA-LILIANA
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

CO2 Emissions, Inequality, and Growth: How Does the Republic of Moldova Compare to the Baltic States and the EU Average? [PDF]

open access: yesOvidius University Annals: Economic Sciences Series
Based on the assumption that the Republic of Moldova lags behind the Baltic states in terms of sustainable and inclusive growth, this research analyzes Moldova’s position regarding CO2 emissions, carbon inequality, income inequality, and economic ...
Rodica Pisică
doaj  

Exploring Collaborative Marketing Strategies for Sustainable Growth in Tea Tourism: A Systematic Literature Review

open access: yesTržište
Purpose – This paper investigates how collaborative marketing strategies shape the tea tourism industry, promote sustainable development, and improve destination competitiveness.
Herman Mahendra Abeykoon
doaj   +1 more source

Sustainable Growth Drivers: Unveiling the Role Played by Carbon Productivity. [PDF]

open access: yesInt J Environ Res Public Health, 2022
Qi W, Song C, Sun M, Wang L, Han Y.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Structural Differences and Economic Growth of the Countries of the Eurasian Economic Union

open access: yesЭкономика: стратегия и практика
In today’s uncertain circumstances, issues related to sustainable economic growth have become more relevant. However, little attention has been paid to the impact of economic integration on the growth of member countries.
K. K. Belgibayeva   +3 more
doaj   +1 more source

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