Results 81 to 90 of about 302,151 (264)

Mining in space could spur sustainable growth. [PDF]

Proc Natl Acad Sci U S A, 2023
Fleming M, Lange I, Shojaeinia S, Stuermer M.   +3 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network dynamics reveal drought synchronization hubs in the Po River Basin

Scientific Reports
The intensifying climate crisis has exacerbated the frequency and severity of prolonged droughts, particularly in environmentally and socio-economically vulnerable climate change hot-spot regions.
Antonio Zinilli, Edmondo Di Giuseppe, Arianna Di Paola, Sara Quaresima, Massimiliano Pasqui   +4 more
doaj   +1 more source

Equine-Assisted Experiential Learning: A Literature Review of Embodied Leadership Development in Organizational Behavior

Administrative Sciences
Background: Equine-assisted experiential learning (EAL) is an emerging approach that uses human–horse interactions to develop leadership skills through experiential methods. Purpose: This review synthesizes the literature on the role of EAL in developing
Rubentheran Sivagurunathan, Abdul Rahman bin S Senathirajah, Linkesvaran Sivagurunathan, Sayeeduzzafar Qazi, Rasheedul Haque   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Anatomy of climate change research in Italian doctoral dissertations using a machine learning approach

Scientific Reports
Climate change is one of the defining challenges of our time, yet little is known about how early-career researchers contribute to this field through doctoral research.
Antonio Zinilli, Giusy Giulia Tuccari, Francesco Poggi, Andrea Giovanni Nuzzolese, Misael Mongiovì, Lorenzo Giammei, Rocco Paolillo, Carmelo Fabio Longo, Miguel Ceriani, Sara Zuppiroli   +9 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Fostering Sustainable Manufacturing in Africa: A Sustainable Supply Chain Management Framework for a Green Future

Administrative Sciences
Sustainable Supply Chain Management (SSCM) emerges as a vital catalyst for inclusive growth and sustainable development, particularly in emerging economies where the manufacturing sector is central to economic progress.
Ahmed Idi Kato, Ntise Hendrick Manchidi
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source