Results 61 to 70 of about 481,387 (312)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Role of the Silk Road Economic Belt in Achieving Sustainable Economic Growth in Central Asia

, 2023
Objective: The study aims to confirm the People's Republic of China's Silk Road Economic Belt initiative as a sustainable development strategy for Central Asian countries, in particular Kazakhstan.
Chaynikova, Liliya, Nadyrov, Sheripzhan, Sorokina, Natalia, Zhang, Bin   +3 more
core   +1 more source

Rediscovering local breeds of naturally free-range hens: a survey on Italian consumers’ awareness of hen welfare and egg purchasing behavior

BMC Veterinary Research
Background Egg production is dominated by the use of conventional cage systems, but the increasing awareness of consumers about animal welfare has led to a shift toward cage-free and free-range systems.
Elena Gosso, Greta Falavigna, Valentina Lamonica, Cristina Lamberti, Simona Cirrincione, Laura Cavallarin, Maria Gabriella Giuffrida, Achille Schiavone   +7 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

As práticas agroecologicas ajudam os pequenos produtores de café na geração de renda? Um estudo de caso em minas gerais

Revista Brasileira de Agroecologia, 2018
Neste artigo foi desenvolvida uma análise de custo-benefício comparando 14 fazendas na Região Leste de Minas Gerais para verificar se as práticas agroecologicas podem estabilizar a renda dos agricultores em comparação com as práticas convencionais. Três
Andrea Pronti
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Sustainable development: mapping different approaches

, 2005
Sustainable development, although a widely used phrase and idea, has many different meanings and therefore provokes many different responses. In broad terms, the concept of sustainable development is an attempt to combine growing concerns about a range ...
O'Brien, Geoff, Mary Mellor, Mellor, Mary, Hopwood, Bill, Bill Hopwood, Mellor, M., Hopwood, B., O'Brien, G., Geoff O'Brien   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source