Results 71 to 80 of about 302,151 (264)
Comparative Economic Research, 2016 The conflict in Ukraine since the beginning of 2014 has been the important in the history of Ukraine as an independent state. Despite the danger of economic collapse, the loss of Crimea, and war in its most industrialized region, Ukraine is still trying ...
Marianna Greta, Mieczysław Pakosz
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Multidimensional Inequality Metrics for Sustainable Business Development
MathematicsThis paper introduces a novel methodology for measuring and decomposing multidimensional inequality, allowing for the breakdown of overall inequality into contributions from distinct dimensions.
Daniel Felix Ahelegbey, Paolo Giudici
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Hyperion Economic Journal, 2013 This paper aims to analyze the economic growth in general as well as in Romania, trying to highlight the elements that stand at the foundation of this process. The beneficial effect of the growth process, resulted in the improvement of living standards and the need to implement measures to improve this process in our country, were decisive elements ...
Liliana Craciun, Anca Gabriela Molanescu
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Sustainable Growth and Chemical Engineering
Chemical Engineering & Technology, 2003 Growth is needed. Connected with economic growth is the concern about our resources, environment, and the effects on human health. Our economy and wealth depend on material resources. Chemistry transforms the resources into the materials and products we need: energy, housing, clothing, food, transport, appliance, and clean water.
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Monitoring and Improving Aircraft Maintenance Processes Using IT Systems
Applied SciencesAircraft maintenance is a complex, multifaceted process that greatly benefits from IT systems designed to improve supervision, record keeping, and task management.
Andrzej Żyluk +3 more
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