Results 41 to 50 of about 1,850,484 (311)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The General Theory of Scientific Variability for Technological Evolution

Sci
The proposed general theory of scientific variability for technological evolution explains one of the drivers of technological change for economic progress in human society. Variability is the predisposition of the elements in systems to assume different
Mario Coccia
doaj   +1 more source

Sustainability appraisal: Jack of all trades, master of none? [PDF]

, 2009
Sustainable development is a commonly quoted goal for decision making and supports a large number of other discourses. Sustainability appraisal has a stated goal of supporting decision making for sustainable development.
Alan J. Bond, Angus Morrison-Saunders, Ayre G., Bartlett R. V., Bekker M. P M, Bell S., Benson D., Bond A. J., Buckingham S., Cabeza Gutés M., Cherp A., Clark J., Clarke A. H., Dalal-Clayton B., Donnelly A., Donnelly A., Foxon T. J., Galobardes B., Gasparatos A., George C., Grey W., Hajer M. A., Jacob M., Kuhn T., Lawrence D. P., Leknes E., Luke T. W., Martin E. J., Mebratu D., Morrison-Saunders A., Morrison-Saunders A., Nykvist B., O'Riordan T., Owens S., Oxley T., Pope J., Pope J., Raina R. S., Ramos T. B., Redclift M. R., Russel D., Sankey H., Sheate W., Steinemann A., Svarstad H., Theobald W. F., Thérivel R., Thérivel R., Williams C. C., Wood C.   +49 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Severe and frequent extreme weather events undermine economic adaptation gains of tree-species diversification

Scientific Reports
Forests and their provision of ecosystem services are endangered by climate change. Tree-species diversification has been identified as a key adaptation strategy to balance economic risks and returns in forest stands.
Jasper M. Fuchs, Kai Husmann, Jan Schick, Matthias Albert, Jussi Lintunen, Carola Paul   +5 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Sustainable growth

Hyperion Economic Journal, 2013
This paper aims to analyze the economic growth in general as well as in Romania, trying to highlight the elements that stand at the foundation of this process. The beneficial effect of the growth process, resulted in the improvement of living standards and the need to implement measures to improve this process in our country, were decisive elements ...
Liliana Craciun, Anca Gabriela Molanescu
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source