Results 41 to 50 of about 1,132,127 (305)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Nutrition of host plants influence the infectivity of nucleopolyhedrovirus to polyphagous caterpillar, Hyphantria cunea

Chemical and Biological Technologies in Agriculture
Plants play an important role in interactions between insect herbivores and their pathogens. The ability of host plants to modify the infectivity of entomopathogens in herbivorous insects has been widely documented.
Xudong Zhao, Yishu Geng, Heng Qiao, Yu Liu, Tianyi Hu, Wenxuan Xu, Dejun Hao   +6 more
doaj   +1 more source

Unlocking the past: key lessons in human-environment dynamics through cultural heritage analysis [PDF]

Urbanization, Sustainability and Society
PurposeThis paper aims to understand human-environment interactions in urban development over time by using historical data, cultural heritage and local knowledge to reduce risk exposure of local communities, prepare for disasters and enhance recovery ...
Giovanni Gugg, Mariana Oliveira, Gabriella Duca   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Cryopreservation and Maturation Media Optimization for Enhanced Somatic Embryogenesis in Masson Pine (Pinus massoniana)

Plants
Pinus massoniana Lamb. (masson pine) is a critical species for afforestation in southern China but faces severe threats from pine wilt disease (PWD) caused by Bursaphelenchus xylophilus.
Qian Yang, Ying Lin, You-Mei Chen, Qi Fei, Jian-Ren Ye, Li-Hua Zhu   +5 more
doaj   +1 more source

Studying learning and innovation networks – a conceptual and methodological framework [PDF]

, 2012
This paper outlines the main concepts and methodology that the SOLINSA project uses in its study of learning and innovation networks. This project aims to identify barriers to the development of Learning and Innovation Networks for sustainable ...
Home, Robert, Moschitz, Heidrun
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Effects of retaining different number of mother bamboo on the growth and NSCs allocation of new-born seedlings in Phyllostachys edulis at different age

BMC Plant Biology
Background Non-structural carbohydrates (NSCs) are key substances for metabolic processes in plants, providing energy for growth, development, and responses to environmental stress.
Binao Zhou, Xu Zhang, Hanjiao Zhang, Wenjing Yao, Long Li, Shuyan Lin, Fuliang Cao   +6 more
doaj   +1 more source

Improving Mangrove Restoration Efficacy Through Husk-Assisted Stability and Arbuscular mycorrhizal Fungi in Nutrient Facilitation [PDF]

BIO Web of Conferences
Mangrove ecosystems are vital for coastal resilience, serving as natural barriers against erosion, nurseries for marine life, carbon sinks, and biodiversity hotspots. However, they are rapidly declining due to natural and human-induced pressures.
Schoenmakers Maikel, Kardjono Xavier, Kohar Kuncoro, Anggono Willyanto, Setiawan Edwin   +4 more
doaj   +1 more source