Results 31 to 40 of about 3,959,814 (238)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A heat shock 70kDa protein MaltHSP70-2 contributes to thermal resistance in Monochamus alternatus (Coleoptera: Cerambycidae): quantification, localization, and functional analysis

BMC Genomics, 2022
Background Heat Shock Proteins 70 (HSP70s) in insects act on a diverse range of substrates to assist with overcoming extreme high temperatures. MaltHSP70-2, a member of HSP70s, has been characterized to involve in the thermotolerance of Monochamus ...
Hui Li, Shouyin Li, Jin Chen, Lulu Dai, Ruixu Chen, Jianren Ye, Dejun Hao   +6 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Policy mixes for sustainable innovation: Conceptual considerations and empirical insights

, 2022
S.165-185This chapter provides an overview of advances in conceptual thinking and empirical applications addressing policy mixes for sustainable innovation.
Rogge, Karoline
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Identification and functional characterization of the histone acetyltransferase gene family in Bursaphelenchus xylophilus

BMC Genomics
Background Acetylation is a widely occurring post-translational protein modification in animals, plants, and microorganisms. Histone acetyltransferase (HATs) are positive regulators of acetylation and are responsible for the growth, development, and ...
Lichao Wang, Yajing Song, Ruocheng Sheng, Muhammad Faizan Latif, Ming Xu, Yang Wang, Min Li, Fengmao Chen   +7 more
doaj   +1 more source

Apigenin Extracts from Myrmecodia pendans and Their Potential Role in Coronary Heart Disease Mitigation [PDF]

BIO Web of Conferences
Myrmecodia pendans is an epiphytic plant indigenous to Papua that contains apigenin, a bioactive compound with antioxidant, anti- inflammatory, and vasodilatory properties.
Santoso Budi, Sarungallo Nirel Andisfyl, Wattimena Beatrix Melany, Anggono Willyanto, Setiawan Edwin   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Improving Mangrove Restoration Efficacy Through Husk-Assisted Stability and Arbuscular mycorrhizal Fungi in Nutrient Facilitation [PDF]

BIO Web of Conferences
Mangrove ecosystems are vital for coastal resilience, serving as natural barriers against erosion, nurseries for marine life, carbon sinks, and biodiversity hotspots. However, they are rapidly declining due to natural and human-induced pressures.
Schoenmakers Maikel, Kardjono Xavier, Kohar Kuncoro, Anggono Willyanto, Setiawan Edwin   +4 more
doaj   +1 more source

Motors of sustainable innovation : Towards a theory on the dynamics of technological innovation systems [PDF]

, 2009
Modern societies are encountering environmental and political problems in the sphere of energy supply. One way to deal with this is to support the development of sustainable energy technologies. Since the development and diffusion of renewable energy has
Dep of Sustainable Development, Suurs, R.A.A., Innovation Studies   +2 more
core   +2 more sources