Results 81 to 90 of about 2,326,597 (280)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Controlled Environment Agriculture for sustainable development: A call for investment and innovation [PDF]

, 2022
Commission on Sustainable Agriculture Intensification
core   +1 more source

A dataset for soil organic carbon in agricultural systems for the Southeast Asia region

Scientific Data
The determination of changes in soil organic carbon (SOC) content under different cropping systems is necessary for policy development oriented towards soil conservation, C sequestration, and future C credit markets. The aim of this study was to generate
Federico Gomez, Ana Carcedo, Chan Makara Mean, Manuel Reyes, Lyda Hok, Florent Tivet, Vang Seng, P. V. Vara Prasad, Ignacio Ciampitti   +8 more
doaj   +1 more source

Factors influencing the adoption and transfer mechanisms for conservation agriculture production systems from early adopters to laggards in Cambodia

Frontiers in Sustainable Food Systems
Adoption of conservation agriculture production systems (CAPS) requires changes in knowledge and resources that affect farmers’ decision-making on agricultural practices, ultimately impacting production, family income, and food security.
Punlork Men, Punlork Men, Punlork Men, Lyda Hok, Lyda Hok, Panchit Seeniang, B. Jan Middendorf, Fidero Kuok, P. V. Vara Prasad, P. V. Vara Prasad, Rapee Dokmaithes   +10 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Eight research and innovation principles for sustainable and equitable agri-food system [PDF]

, 2022
Commission on Sustainable Agriculture Intensification
core   +1 more source

Governing for the future : the opportunities for mainstreaming sustainable development [PDF]

, 2012
Following the statement by the Secretary of State for Environment, Food & Rural Affairs on 22 July 2010 stating that Government wants "to mainstream sustainability, strengthen the Government's performance in this area and put processes in place to join ...
Sustainable Development Commission
core   +2 more sources

Technical feasibility and economic analysis of solar photovoltaic water pumping system for sustainable irrigation in Nepal: a case study

International Journal of Sustainable Engineering
Solar-powered irrigation can transform smallholder agriculture in off-grid regions, yet few studies integrate detailed field validation with comprehensive techno-economic analysis under South Asian monsoon climates.
Padam Prasad Paudel, Subash Adhikari
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source