Results 61 to 70 of about 2,326,597 (280)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Participatory multicriteria assessment of maize cropping systems in the context of family farmers in the Brazilian Cerrado

International Journal of Agricultural Sustainability, 2020
Conservation agriculture (CA) is recognized as a promising crop management strategy for sustainable agricultural intensification. The objective of this study was to evaluate CA cropping systems for rainfed maize as an alternative to the traditional ...
José Humberto Valadares Xavier, Mário Conill Gomes, Flávio Sacco dos Anjos, Eric Scopel, Fernando Antônio Macena da Silva, Marc Corbeels   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Assessment of nutrition knowledge, perceptions of wild food plants, and associated influencing factors among secondary school students in Cambodia

Frontiers in Sustainable Food Systems
The nutritionally rich wild food plants (WFPs) are underutilized, particularly among school-aged children in Cambodia. While previous studies have documented the general value of WFPs, empirical evidence on how school-based training interventions ...
Sreypich Chhun, Sreypich Chhun, Lyda Hok, Phanith Chou, David R. Ader, David R. Ader, Punlork Men, Leangsrun Chea, Manuel R. Reyes, P. V. Vara Prasad   +9 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Case Study: United States Agency for International Development (USAID) investment in innovation for sustainable agricultural intensification [PDF]

, 2021
USAID has played a crucial role in shaping global shifts in agriculture and sustainable agricultural intensification (SAI) through the decades. The agency has constantly fostered agricultural innovation - from the Green Revolution in the 1960s to the ...
Dalberg Asia
core   +1 more source

Education & Skills Committee inquiry on sustainable schools : submission from the Sustainable Development Commission [PDF]

, 2012
This submission to the Education & Skills Committee looks at sustainable development, sustainable schools, school buildings, and provides recommendations on these issues.Publisher ...
Sustainable Development Commission
core   +2 more sources

Food and energy security sustainable intensification special issue editorial

Food and Energy Security, 2019
In November 2017 the Association of Applied Biologists and the Sustainable Intensification Research Platform (SIP) held a conference on Sustainable Intensification (SI) at Rothamsted Research.
Robert Carlton
doaj   +1 more source