Results 91 to 100 of about 4,579 (301)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A Dynamic Simulation Model for Understanding Sustainability of Machining Operation

, 2022
The environmental impact of machining operations such as milling, drilling, and turning, is often treated as a conflicting interest when compared to other machining factors such as cost, quality, time, and process settings.
Rod MacDonald, Tess Moran, Hao Zhang
core   +1 more source

Optimizing sustainable machining for magnesium alloys: a comparative study of GRA and TOPSIS

Cogent Engineering
This study delves into a comparative analysis of two multi-criteria decision analysis methods, Grey Relational Analysis (GRA) and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS), to fine-tune sustainable machining parameters ...
M. Atif Saeed, Faraz Junejo, Imran Amin
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A Holistic Perspective on Sustainable Machining of Al6082: Synergistic Effects of Nano-Enhanced Bio-Lubricants

Machines
This study investigates the performance of biobased and nano-additive lubricants for the sustainable machining of Al6082 alloy. The experiments were conducted in five different cutting environments: dry cutting, olive oil-based minimum quantity ...
Rüstem Binali, Mehmet Erdi Korkmaz, Mehmet Tayyip Özdemir, Mustafa Günay   +3 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

On the Use of Compressed Air and Synthetic Biodegradable Cutting Fluid to Enhance the Surface Quality of WAAM–CMT Manufactured Low-Alloy Steel Parts During Post-Processing Milling with Different Cooling–Lubrication Strategies

Journal of Manufacturing and Materials Processing
Additive manufacturing (AM) stands out for its variable applications in terms of material, quality, and geometry. Wire Arc Additive Manufacturing (WAAM) is remarkable for producing large parts in reduced times when compared to other AM methods.
Déborah de Oliveira, Marcos Vinícius Gonçalves, Guilherme Menezes Ribeiro, André Luis Silva da Costa, Luis Regueiras, Tiago Silva, Abílio de Jesus, Lucival Malcher, Maksym Ziberov   +8 more
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

An optimization model for energy-efficient machining for sustainable production

, 2019
Sustainable production plays an important role in product lifecycle management by considering the social sustainability. Energy-efficient machining is an efficient approach for sustainable production in current manufacturing sectors.
Wang, H, Tian, X, Zhong, RY, Liu, G, Mu, W, Leng, D   +5 more
core   +1 more source

Assessment of surface quality and damages induced during dry helical milling of hybrid composite fiber metal laminates

Materials Research Express
The present work investigates the effectiveness of helical milling for making holes with excellent surface quality in carbon fiber aluminum laminates (CARALL) under dry cutting conditions.
Satish Shenoy Baloor, Suleyman Cinar Cagan, Gururaj Bolar, Madhusudhan Balkundhi, Anoop Aroor Dinesh   +4 more
doaj   +1 more source